6M5 · (4~{A}~{S},8~{A}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl) phenoxy]butoxy]phenyl]-4~{A},5,8,8~{A}-tetrahydrophthalazin-1-one

Binding sites

6M5 in 4 structures; the first of them:

• 5LAQ · Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001 · 6M5 A1005 · binds MET519, ASP564, LEU565, ASN567, TRP578, THR579, ILE582, MET583 and 7 more
• 5LBO · Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001 · 6M5 A1011 · binds TYR159, HIS160, THR271, MET273, ASP318, LEU319, ASN321, TYR329 and 12 more
• 5LAQ · Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor npd-001 · 6M5 A1005 · binds MET519, ASP564, LEU565, ASN567, TRP578, THR579, ILE582, MET583 and 7 more
• 5LBO · Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor npd-001 · 6M5 A1011 · binds TYR159, HIS160, MET273, ASP318, LEU319, ASN321, THR333, ILE336 and 8 more

Residues it binds most

MET 10, TYR 10, ILE 10, PHE 10, THR 10, ASN 10, ASP 10, GLN 10, GLY 10, LEU 10 (residue and the binding sites it lines).

Found with

• MG · Magnesium ion
• ZN · Zinc ion
• ACT · Acetate ion
• DTT · 2,3-dihydroxy-1,4-dithiobutane
• EDO · 1,2-ethanediol
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
• PEG · Di(hydroxyethyl)ether