UniProt P42260
Glutamate receptor ionotropic, kainate 2 (P42260)
Glutamate receptor ionotropic, kainate 2 (UniProt P42260): 85 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 94 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P42260
- Protein
- Glutamate receptor ionotropic, kainate 2
- Experimental structures
- 85
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 94 · 6 records with a druggable one
Structures
86 records of P42260 in the MolNFT archive: 85 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S50 | X-ray structure of the GluR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 A… | x-ray diffraction | A | — | — |
| 1S50 | X-ray structure of the GLUR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 a… | x-ray diffraction | A | — | — |
| 1S7Y | Crystal structure of the GluR6 ligand binding core in complex with glutamate at 1.75 A resolution… | x-ray diffraction | A, B | — | — |
| 1S7Y | Crystal structure of the GLUR6 ligand binding core in complex with glutamate at 1.75 a resolution… | x-ray diffraction | A, B | — | — |
| 1S9T | Crystal structure of the GLUR6 ligand binding core in complex with quisqualate at 1.8A resolution | x-ray diffraction | A, B | — | — |
| 1S9T | Crystal structure of the GLUR6 ligand binding core in complex with quisqualate at 1.8A resolution | x-ray diffraction | A, B | — | — |
| 1SD3 | Crystal structure of the GLUR6 ligand binding core in complex with 2S,4R-4-methylglutamate at 1.8… | x-ray diffraction | A, B | — | — |
| 1SD3 | Crystal structure of the GLUR6 ligand binding core in complex with 2S, 4R-4-methylglutamate at 1.8… | x-ray diffraction | A, B | — | — |
| 1TT1 | Crystal structure of the GLUR6 ligand binding core in complex with kainate 1.93 a resolution | x-ray diffraction | A, B | — | — |
| 1TT1 | Crystal structure of the GLUR6 ligand binding core in complex with kainate 1.93 a resolution | x-ray diffraction | A, B | — | — |
| 2I0B | Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution | x-ray diffraction | A, B, C | — | — |
| 2I0B | Crystal structure of the GLUR6 ligand binding core elkq mutant dimer at 1.96 ångströms resolution | x-ray diffraction | A, B, C | — | — |
| 2I0C | Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between… | x-ray diffraction | A, B | — | — |
| 2I0C | Crystal structure of the GLUR6 ligand binding core dimer crosslinked by disulfide bonds between… | x-ray diffraction | A, B | — | — |
| 2XXR | Crystal structure of the GluK2 (GluR6) wild-type LBD dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXR | Crystal structure of the GLUK2 (GLUR6) wild-type lbd dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXT | Crystal structure of the GluK2 (GluR6) wild-type LBD dimer in complex with kainate | x-ray diffraction | A, B | — | — |
| 2XXT | Crystal structure of the GLUK2 (GLUR6) wild-type lbd dimer in complex with kainate | x-ray diffraction | A, B | — | — |
| 2XXU | Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXU | Crystal structure of the GLUK2 (GLUR6) M770K lbd dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXV | Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with kainate | x-ray diffraction | A, B | — | — |
| 2XXV | Crystal structure of the GLUK2 (GLUR6) M770K lbd dimer in complex with kainate | x-ray diffraction | A, B | — | — |
| 2XXW | Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXW | Crystal structure of the GLUK2 (GLUR6) D776K lbd dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 2XXX | Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate (P21 21 21) | x-ray diffraction | A, B, C, D | — | — |
| 2XXX | Crystal structure of the GLUK2 (GLUR6) D776K lbd dimer in complex with glutamate (P21 21 21) | x-ray diffraction | A, B, C, D | — | — |
| 2XXY | Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 2XXY | Crystal structure of the GLUK2 (GLUR6) D776K lbd dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 3G3F | Crystal structure of the GluR6 ligand binding domain dimer with glutamate and NaCl at 1.38 Angstrom… | x-ray diffraction | A, B | — | — |
| 3G3F | Crystal structure of the GLUR6 ligand binding domain dimer with glutamate and nacl at 1.38 ångström… | x-ray diffraction | A, B | — | — |
| 3G3G | Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at… | x-ray diffraction | A, B | — | — |
| 3G3G | Crystal structure of the GLUR6 ligand binding domain dimer K665R mutant with glutamate and nacl at… | x-ray diffraction | A, B | — | — |
| 3G3H | Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate… | x-ray diffraction | A, B | — | — |
| 3G3H | Crystal structure of the GLUR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate… | x-ray diffraction | A, B | — | — |
| 3G3I | Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with… | x-ray diffraction | A, B | — | — |
| 3G3I | Crystal structure of the GLUR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with… | x-ray diffraction | A, B | — | — |
| 3G3J | Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant… | x-ray diffraction | A, B | — | — |
| 3G3J | Crystal structure of the GLUR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant… | x-ray diffraction | A, B | — | — |
| 3G3K | Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q… | x-ray diffraction | A, B | — | — |
| 3G3K | Crystal structure of the GLUR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q… | x-ray diffraction | A, B | — | — |
| 3H6G | Crystal structure of the GluR6 amino terminal domain dimer assembly | x-ray diffraction | A, B | — | — |
| 3H6G | Crystal structure of the GLUR6 amino terminal domain dimer assembly | x-ray diffraction | A, B | — | — |
| 3H6H | Crystal structure of the GluR6 amino terminal domain dimer assembly MPD form | x-ray diffraction | A, B | — | — |
| 3H6H | Crystal structure of the GLUR6 amino terminal domain dimer assembly mpd form | x-ray diffraction | A, B | — | — |
| 3QLT | Crystal structure of a GluK2 (GluR6) glycan wedge homodimer assembly | x-ray diffraction | A, B | — | — |
| 3QLT | Crystal structure of a GLUK2 (GLUR6) glycan wedge homodimer assembly | x-ray diffraction | A, B | — | — |
| 3QLU | Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD dimer assembly | x-ray diffraction | C, D | — | — |
| 3QLU | Crystal structure of the GLUK2/GLUK5 (GLUR6/KA2) atd dimer assembly | x-ray diffraction | C, D | — | — |
| 3QLV | Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD tetramer assembly | x-ray diffraction | C, D, F, H, J | — | — |
| 3QLV | Crystal structure of the GLUK2/GLUK5 (GLUR6/KA2) atd tetramer assembly | x-ray diffraction | C, D, F, H, J | — | — |
| 4BDL | Crystal structure of the GluK2 K531A LBD dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 4BDL | Crystal structure of the GLUK2 K531A lbd dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 4BDM | Crystal structure of the GluK2 K531A LBD dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 4BDM | Crystal structure of the GLUK2 K531A lbd dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 4BDN | Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with glutamate | x-ray diffraction | A, B, C, D | — | — |
| 4BDN | Crystal structure of the GLUK2 K531A-T779G lbd dimer in complex with glutamate | x-ray diffraction | A, B, C, D | — | — |
| 4BDO | Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 4BDO | Crystal structure of the GLUK2 K531A-T779G lbd dimer in complex with kainate | x-ray diffraction | A, B, C, D | — | — |
| 4BDQ | Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
| 4BDQ | Crystal structure of the GLUK2 R775A lbd dimer in complex with glutamate | x-ray diffraction | A, B | — | — |
26 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 11 records
- BMA · beta-D-mannopyranose · in 10 records
- 2J9 · 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide · in 5 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- CL · Chloride ion · in 3 records
- NA · Sodium ion · in 3 records
- CLR · Cholesterol · in 2 records
- GLU · Glutamic acid · in 2 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 2 records
- 6ZP · 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile · in 1 record
- A1BDT · N,N'-[butane-1,4-diylbis(azanediylpropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] · in 1 record
- AH2 · 1-deoxy-alpha-D-mannopyranose · in 1 record
- CA · Calcium ion · in 1 record
- DNQ · 6,7-dinitroquinoxaline-2,3-dione · in 1 record
- LY5 · (3s,4ar,6s,8ar)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- SPM · Spermine · in 1 record
Experiment against prediction
- 4BDM chain A against the predicted model P42260: TM-score 0.98, RMSD 0.67 Å
- 3QLT chain B against the predicted model P42260: TM-score 0.98, RMSD 0.95 Å
- 4BDO chain A against the predicted model P42260: TM-score 0.98, RMSD 0.69 Å
- 3QLT chain A against the predicted model P42260: TM-score 0.98, RMSD 1.00 Å
- 4BDR chain B against the predicted model P42260: TM-score 0.98, RMSD 0.74 Å
- 4BDM chain B against the predicted model P42260: TM-score 0.98, RMSD 0.75 Å
- 4BDO chain B against the predicted model P42260: TM-score 0.98, RMSD 0.78 Å
- 2XXV chain B against the predicted model P42260: TM-score 0.98, RMSD 0.81 Å
- 2XXV chain B against the predicted model P42260: TM-score 0.98, RMSD 0.81 Å
- 3H6H chain B against the predicted model P42260: TM-score 0.98, RMSD 1.18 Å
Elsewhere
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