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Ligand · SYM

SYM · 2S,4R-4-methylglutamate

SYM, 2S,4R-4-methylglutamate (C6 H10 N O4 -1, 160.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
SYM
Formula
C6 H10 N O4 -1
Class
ligand
Structures
8
PDB entries
4

Binding sites

SYM in 8 structures; the first of them:

  • 1SD3 · Crystal structure of the GLUR6 ligand binding core in complex with… · SYM A998 · binds TYR61, PRO89, LEU90, ALA91, ARG96, VAL138, GLY141, ALA142 and 5 more
  • 5CMM · Crystal structure of the GluK2EM LBD dimer assembly complex with 2S,4R-4-methylglutamate · SYM A301 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, VAL138, GLY141 and 5 more
  • 5KUF · GluK2EM with 2S,4R-4-methylglutamate · SYM A901 · binds TYR457, PRO485, LEU486, THR487, ARG492, VAL654, GLY657, SER658 and 3 more
  • 6JMV · Crystal structure of the GluK3 ligand binding domain complex with SYM and zinc · SYM A301 · binds TYR61, PRO88, LEU89, THR90, ARG95, VAL137, GLY140, ALA141 and 4 more
  • 1SD3 · Crystal structure of the GLUR6 ligand binding core in complex with 2S… · SYM A998 · binds TYR61, PRO89, LEU90, ALA91, ARG96, VAL138, GLY141, ALA142 and 5 more
  • 5CMM · Crystal structure of the GLUK2EM lbd dimer assembly complex with 2S, 4R-4-methylglutamate · SYM A301 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, VAL138, GLY141 and 5 more
  • 5KUF · GLUK2EM with 2S,4R-4-methylglutamate · SYM A901 · binds TYR457, PRO485, LEU486, THR487, ARG492, VAL654, GLY657, SER658 and 3 more
  • 6JMV · Crystal structure of the GLUK3 ligand binding domain complex with sym and zinc · SYM A301 · binds TYR61, PRO88, LEU89, THR90, ARG95, VAL137, GLY140, ALA141 and 4 more

Residues it binds most

THR 18, TYR 18, LEU 18, GLU 18, ARG 18, GLY 18, PRO 18, VAL 18, ALA 12, SER 10 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • ZN · Zinc ion
  • CL · Chloride ion
  • ACT · Acetate ion
  • GOL · Glycerol

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