UniProt P19821
DNA polymerase I, thermostable (P19821)
DNA polymerase I, thermostable (UniProt P19821), EC 2.7.7.7: 138 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P19821
- Protein
- DNA polymerase I, thermostable
- EC
- 2.7.7.7
- Experimental structures
- 138
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 44 · 6 records with a druggable one
Structures
139 records of P19821 in the MolNFT archive: 138 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BGX | Taq polymerase in complex with TP7, an inhibitory Fab | x-ray diffraction | T | — | — |
| 1BGX | Taq polymerase in complex with TP7, an inhibitory Fab | x-ray diffraction | T | — | — |
| 1JXE | Stoffel fragment of taq DNA polymerase I | x-ray diffraction | A | — | — |
| 1JXE | Stoffel fragment of taq DNA polymerase I | x-ray diffraction | A | — | — |
| 1KTQ | DNA polymerase | x-ray diffraction | A | — | — |
| 1KTQ | DNA polymerase | x-ray diffraction | A | — | — |
| 1QSS | Ddgtp-trapped closed ternary complex of the large fragment of DNA polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1QSS | Ddgtp-trapped closed ternary complex of the large fragment of DNA polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1QSY | DDATP-Trapped closed ternary complex of the large fragment of DNA Polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1QSY | Ddatp-trapped closed ternary complex of the large fragment of DNA polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1QTM | Ddttp-trapped closed ternary complex of the large fragment of DNA polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1QTM | Ddttp-trapped closed ternary complex of the large fragment of DNA polymerase I from thermus… | x-ray diffraction | A | — | — |
| 1TAQ | Structure of taq DNA polymerase | x-ray diffraction | A | — | — |
| 1TAQ | Structure of taq DNA polymerase | x-ray diffraction | A | — | — |
| 1TAU | Taq polymerase (E.C.2.7.7.7)/DNA/B-octylglucoside complex | x-ray diffraction | A | — | — |
| 1TAU | Taq polymerase (E.C.2.7.7.7)/DNA/B-octylglucoside complex | x-ray diffraction | A | — | — |
| 2KTQ | Open ternary complex of the large fragment of DNA polymerase I from thermus aquaticus | x-ray diffraction | A | — | — |
| 2KTQ | Open ternary complex of the large fragment of DNA polymerase I from thermus aquaticus | x-ray diffraction | A | — | — |
| 3KTQ | Crystal structure of an active ternary complex of the large fragment of DNA polymerase I from… | x-ray diffraction | A | — | — |
| 3KTQ | Crystal structure of an active ternary complex of the large fragment of DNA polymerase I from… | x-ray diffraction | A | — | — |
| 3LWL | Structure of Klenow fragment of Taq polymerase in complex with an abasic site | x-ray diffraction | A | — | — |
| 3LWL | Structure of klenow fragment of taq polymerase in complex with an abasic site | x-ray diffraction | A | — | — |
| 3LWM | Structure of the large fragment of thermus aquaticus DNA polymerase I in complex with a blunt-ended… | x-ray diffraction | A | — | — |
| 3LWM | Structure of the large fragment of thermus aquaticus DNA polymerase I in complex with a blunt-ended… | x-ray diffraction | A | — | — |
| 3M8R | Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3M8R | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3M8S | Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3M8S | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3OJS | Snapshots of the large fragment of DNA polymerase I from Thermus Aquaticus processing C5 modified… | x-ray diffraction | A | — | — |
| 3OJS | Snapshots of the large fragment of DNA polymerase I from thermus aquaticus processing C5 modified… | x-ray diffraction | A | — | — |
| 3OJU | Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing c5 modified… | x-ray diffraction | A | — | — |
| 3OJU | Snapshot of the large fragment of DNA polymerase I from thermus aquaticus processing C5 modified… | x-ray diffraction | A | — | — |
| 3PO4 | Structure of a mutant of the large fragment of DNA polymerase I from Thermus aquaticus in complex… | x-ray diffraction | A | — | — |
| 3PO4 | Structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in complex… | x-ray diffraction | A | — | — |
| 3PO5 | Structure of a mutant of the large fragment of DNA polymerase I from Thermus Auqaticus in complex… | x-ray diffraction | A | — | — |
| 3PO5 | Structure of a mutant of the large fragment of DNA polymerase I from thermus auqaticus in complex… | x-ray diffraction | A | — | — |
| 3PY8 | Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a… | x-ray diffraction | A | — | — |
| 3PY8 | Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a… | x-ray diffraction | A | — | — |
| 3RR7 | Binary Structure of the large fragment of Taq DNA polymerase bound to an abasic site | x-ray diffraction | A | — | — |
| 3RR7 | Binary structure of the large fragment of taq DNA polymerase bound to an abasic site | x-ray diffraction | A | — | — |
| 3RR8 | Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP | x-ray diffraction | A | — | — |
| 3RR8 | Ternary structure of the large fragment of taq DNA polymerase bound to an abasic site and a ddgtp | x-ray diffraction | A | — | — |
| 3RRG | Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP | x-ray diffraction | A | — | — |
| 3RRG | Ternary structure of the large fragment of taq DNA polymerase bound to an abasic site and a ddgtp | x-ray diffraction | A | — | — |
| 3RRH | Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddTTP | x-ray diffraction | A | — | — |
| 3RRH | Ternary structure of the large fragment of taq DNA polymerase bound to an abasic site and a ddttp | x-ray diffraction | A | — | — |
| 3RTV | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3RTV | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3SV3 | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3SV3 | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in a closed… | x-ray diffraction | A | — | — |
| 3SV4 | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open… | x-ray diffraction | A | — | — |
| 3SV4 | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in an open… | x-ray diffraction | A | — | — |
| 3SYZ | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open… | x-ray diffraction | A | — | — |
| 3SYZ | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in an open… | x-ray diffraction | A | — | — |
| 3SZ2 | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open… | x-ray diffraction | A | — | — |
| 3SZ2 | Crystal structure of the large fragment of DNA polymerase I from thermus aquaticus in an open… | x-ray diffraction | A | — | — |
| 3T3F | Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and dNITP | x-ray diffraction | A | — | — |
| 3T3F | Ternary structure of the large fragment of taq DNA polymerase bound to an abasic site and dnitp | x-ray diffraction | A | — | — |
| 4BWJ | KlenTaq mutant in complex with DNA and ddCTP | x-ray diffraction | A | — | — |
| 4BWJ | Klentaq mutant in complex with DNA and ddctp | x-ray diffraction | A | — | — |
79 records more on the page itself.
Ligands
- MG · Magnesium ion · in 24 records
- MN · Manganese (II) ion · in 13 records
- XG4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine · in 8 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 5 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 4 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 3 records
- 2IU · [[(2R,3S,5R)-5-[5-(1-benzofuran-2-yl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 2 records
- 91R · [[(2~{R},3~{S},5~{R})-5-[4-[(4~{S})-4,5-bis(oxidanyl) pent-1-ynyl]-2-nitro-pyrrol-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 2 records
- 91T · [[(2~{R},3~{S},5~{R})-5-[4-[(4~{R})-4,5-bis(oxidanyl) pent-1-ynyl]-2-nitro-pyrrol-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 2 records
- HHZ · [[(2~{R},3~{S},5~{R})-5-[4-azanyl-5-[3-[2-(2-hydroxyethyloxy)ethanoylamino]prop-1-ynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 2 records
- NZI · [(2~{R},3~{S},5~{R})-3-oxidanyl-5-(2-oxidanylidene-3~{H}-benzimidazol-1-yl)oxolan-2-yl]methyl [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate · in 2 records
- 72J · 7-(N-(10-hydroxydecanoyl)-aminopentenyl)-7-deaza-2'-datp · in 1 record
- A1IDW · [[(2~{R},3~{S},5~{R})-5-[5-(5-fluoranyl-1-benzofuran-2-yl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
- A5J · (1R)-1-[6-amino-5-(dihydroxyamino)-2-hydroxypyridin-3-yl]-1,4-anhydro-2-deoxy-5-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-erythro-pentitol · in 1 record
- AUL · 2'-deoxy-5-{(1E)-5-[(10-hydroxydecanoyl)amino]pent-1-en-1-yl}uridine 5'-(tetrahydrogen triphosphate) · in 1 record
Experiment against prediction
- 3SZ2 chain A against the predicted model P19821: TM-score 1.00, RMSD 0.58 Å
- 3SZ2 chain A against the predicted model P19821: TM-score 1.00, RMSD 0.58 Å
- 5W6Q chain A against the predicted model P19821: TM-score 1.00, RMSD 0.56 Å
- 4CCH chain A against the predicted model P19821: TM-score 1.00, RMSD 0.57 Å
- 4CCH chain A against the predicted model P19821: TM-score 1.00, RMSD 0.57 Å
- 5W6Q chain C against the predicted model P19821: TM-score 0.99, RMSD 0.58 Å
- 4N56 chain A against the predicted model P19821: TM-score 0.99, RMSD 0.61 Å
- 4N56 chain A against the predicted model P19821: TM-score 0.99, RMSD 0.61 Å
- 3RR7 chain A against the predicted model P19821: TM-score 0.99, RMSD 0.62 Å
- 3RR7 chain A against the predicted model P19821: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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