UniProt P0C7B7
Cys-loop ligand-gated ion channel (P0C7B7)
Cys-loop ligand-gated ion channel (UniProt P0C7B7): 34 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 100 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0C7B7
- Protein
- Cys-loop ligand-gated ion channel
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 100 · 5 records with a druggable one
Structures
35 records of P0C7B7 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VL0 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2VL0 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2YKS | Pentameric ligand gated ion channel elic mutant F246A | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2YKS | Pentameric ligand gated ion channel elic mutant F246A | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2YOE | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2YOE | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3ZKR | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3ZKR | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4A97 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4A97 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4A98 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4A98 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWD | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWD | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWF | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWF | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWH | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4TWH | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4YEU | ELIC-GLIC chimera in the resting conformation | x-ray diffraction | A, B, C, D, E | — | — |
| 4YEU | Elic-glic chimera in the resting conformation | x-ray diffraction | A, B, C, D, E | — | — |
| 5LID | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | 6XY | — |
| 5LID | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | 6XY | — |
| 5SXV | X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (elic) in a… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | BRJ | — |
| 6HJX | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore… | x-ray diffraction | A, B, C, D, E | PTY, NA | 20 (best 0.86) |
| 6HJX | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) 7'C pore… | x-ray diffraction | A, B, C, D, E | PTY | — |
| 6HJY | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8… | x-ray diffraction | A, B, C, D, E | — | 20 (best 0.86) |
| 6HJY | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) DELTA8… | x-ray diffraction | A, B, C, D, E | — | — |
| 6HK0 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | 20 (best 0.83) |
| 6HK0 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) F16'S… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 6SSI | Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody | x-ray diffraction | A, B, C, D, E | ABU, CA, UMQ | — |
| 6SSI | Structure of the pentameric ligand-gated ion channel elic in complex with a pam nanobody | x-ray diffraction | A, B, C, D, E | ABU, CA, UMQ | — |
| 6SSP | Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | CA, UMQ | 20 (best 0.84) |
| 6SSP | Structure of the pentameric ligand-gated ion channel elic in complex with a nam nanobody | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | CA, UMQ | — |
| 8VUW | ELIC5 with cysteamine in 2:1:1 POPC:POPE:POPG nanodisc in open conformation | electron microscopy | A, B, C, D, E | PGW, DHL | 20 (best 0.74) |
| P0C7B7 | AlphaFold monomer V2.0 prediction for cys-loop ligand-gated ion channel (P0C7B7) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- UMQ · Undecyl-maltoside · in 4 records
- 6XY · bromopromazine · in 2 records
- ABU · Gamma-amino-butanoic acid · in 2 records
- PTY · Phosphatidylethanolamine · in 2 records
- BRJ · 2-bromoethanol · in 1 record
- DHL · 2-amino-ethanethiol · in 1 record
- NA · Sodium ion · in 1 record
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 1 record
Experiment against prediction
- 6HJY chain E against the predicted model P0C7B7: TM-score 0.99, RMSD 0.54 Å
- 6HJY chain E against the predicted model P0C7B7: TM-score 0.99, RMSD 0.54 Å
- 6HJY chain B against the predicted model P0C7B7: TM-score 0.99, RMSD 0.65 Å
- 6HJY chain B against the predicted model P0C7B7: TM-score 0.99, RMSD 0.65 Å
- 6HJY chain A against the predicted model P0C7B7: TM-score 0.99, RMSD 0.67 Å
- 6HJY chain A against the predicted model P0C7B7: TM-score 0.99, RMSD 0.67 Å
- 6HJY chain D against the predicted model P0C7B7: TM-score 0.98, RMSD 0.67 Å
- 6HJY chain D against the predicted model P0C7B7: TM-score 0.98, RMSD 0.67 Å
- 6HJY chain C against the predicted model P0C7B7: TM-score 0.98, RMSD 0.75 Å
- 6HJY chain C against the predicted model P0C7B7: TM-score 0.98, RMSD 0.75 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.