MolNFT v1 · #111044 · protein
Elic-glic chimera in the resting conformation
4YEU · Cys-loop ligand-gated ion CHANNEL,PROTON-gated ion channel: “Elic-glic chimera in the resting conformation”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #111044 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4YEU
- Type
- protein
- Length
- 1,560 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cys-loop ligand-gated ion CHANNEL,PROTON-gated ion channel
- UniProt
- P0C7B7, Q7NDN8
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Cys-loop ligand-gated ion CHANNEL,PROTON-gated ion channel | protein | 312 | 36% helix, 31% strand | P0C7B7, Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 892 | 0.82 | 0.84 | 98 | empty |
| 2 | 780 | 0.81 | 0.84 | 80 | empty |
| 3 | 962 | 0.80 | 0.82 | 87 | empty |
| 4 | 647 | 0.80 | 0.85 | 54 | empty |
| 5 | 1180 | 0.80 | 0.81 | 108 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2656 Ų buried · 19 hydrogen bonds · protein-protein
- A–E · 2629 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2604 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 2600 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 2592 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 4YEU · ELIC-GLIC chimera in the resting conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P0C7B7 · AlphaFold monomer V2.0 prediction for cys-loop ligand-gated ion channel (P0C7B7) · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C7B7
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 4YEU · PDBe 4YEU · UniProt P0C7B7 · UniProt Q7NDN8
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