UniProt Q7NDN8
Proton-gated ion channel (Q7NDN8)
Proton-gated ion channel (UniProt Q7NDN8): 221 experimental structures and 1 predicted model on GenesisL1, 24 ligands bound, 913 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7NDN8
- Protein
- Proton-gated ion channel
- Experimental structures
- 221
- Predicted models
- 1
- Ligands
- 24
- Pockets
- 913 · 46 records with a druggable one
Structures
222 records of Q7NDN8 in the MolNFT archive: 221 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XQ3 | Pentameric ligand gated ion channel GLIC in complex with Br-lidocaine | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ3 | Pentameric ligand gated ion channel glic in complex with br-lidocaine | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ4 | Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ4 | Pentameric ligand gated ion channel glic in complex with tetramethylarsonium (tmas) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ5 | Pentameric ligand gated ion channel GLIC in complex with tetraethylarsonium (TEAs) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ5 | Pentameric ligand gated ion channel glic in complex with tetraethylarsonium (teas) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ6 | Pentameric ligand gated ion channel GLIC in complex with cesium ion (Cs+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ6 | Pentameric ligand gated ion channel glic in complex with cesium ion (cs+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ7 | Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ7 | Pentameric ligand gated ion channel glic in complex with cadmium ion (CD2+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ8 | Pentameric ligand gated ion channel GLIC in complex with zinc ion (Zn2+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ8 | Pentameric ligand gated ion channel glic in complex with zinc ion (ZN2+) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ9 | Pentameric ligand gated ion channel GLIC mutant E221A in complex with tetraethylarsonium (TEAs) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQ9 | Pentameric ligand gated ion channel glic mutant E221A in complex with tetraethylarsonium (teas) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQA | Pentameric ligand gated ion channel GLIC in complex with tetrabutylantimony (TBSb) | x-ray diffraction | A, B, C, D, E | — | — |
| 2XQA | Pentameric ligand gated ion channel glic in complex with tetrabutylantimony (tbsb) | x-ray diffraction | A, B, C, D, E | — | — |
| 3EAM | An open-pore structure of a bacterial pentameric ligand-gated ion channel | x-ray diffraction | A, B, C, D, E | — | — |
| 3EAM | An open-pore structure of a bacterial pentameric ligand- gated ion channel | x-ray diffraction | A, B, C, D, E | — | — |
| 3EHZ | X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a… | x-ray diffraction | A, B, C, D, E | — | — |
| 3EHZ | X-ray structure of the pentameric ligand gated ion channel of gloebacter violaceus (glic) in a… | x-ray diffraction | A, B, C, D, E | — | — |
| 3EI0 | Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion channnel… | x-ray diffraction | A, B, C, D, E | — | — |
| 3EI0 | Structure of the E221A mutant of the gloebacter violaceus pentameric ligand gated ion channnel… | x-ray diffraction | A, B, C, D, E | — | — |
| 3IGQ | Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3IGQ | Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3LSV | Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus | x-ray diffraction | A, B, C, D, E | — | — |
| 3LSV | Structure of the A237F mutant of the pentameric ligand gated ion channel from gloeobacter violaceus | x-ray diffraction | A, B, C, D, E | — | — |
| 3P4W | Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC | x-ray diffraction | A, B, C, D, E | — | — |
| 3P4W | Structure of desflurane bound to a pentameric ligand-gated ion channel, glic | x-ray diffraction | A, B, C, D, E | — | — |
| 3P50 | Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC | x-ray diffraction | A, B, C, D, E | — | — |
| 3P50 | Structure of propofol bound to a pentameric ligand-gated ion channel, glic | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLS | The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLS | The glic pentameric ligand-gated ion channel E19'P mutant in a locally-closed conformation (LC2… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLT | The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLT | The glic pentameric ligand-gated ion channel H11'F mutant in a locally-closed conformation (LC1… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLU | The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLU | The glic pentameric ligand-gated ion channel LOOP2-24' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLV | The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLV | The glic pentameric ligand-gated ion channel LOOP2-22' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLW | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3TLW | The glic pentameric ligand-gated ion channel LOOP2-21' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU3 | The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU3 | The glic pentameric ligand-gated ion channel LOOP2-20' oxidized mutant in a locally-closed… | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU4 | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in the crystal in a… | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU4 | The glic pentameric ligand-gated ion channel LOOP2-21' mutant reduced in the crystal in a… | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU5 | The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU5 | The glic pentameric ligand-gated ion channel LOOP2-20' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU6 | The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU6 | The glic pentameric ligand-gated ion channel LOOP2-22' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU8 | The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UU8 | The glic pentameric ligand-gated ion channel LOOP2-24' mutant reduced in solution | x-ray diffraction | A, B, C, D, E | — | — |
| 3UUB | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UUB | The glic pentameric ligand-gated ion channel LOOP2-21' mutant reduced in solution | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4F8H | X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel | x-ray diffraction | A, B, C, D, E | — | — |
| 4F8H | X-ray structure of the anesthetic ketamine bound to the glic pentameric ligand-gated ion channel | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFB | The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo) | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFB | The glic pentameric ligand-gated ion channel F14'A ethanol-sensitive mutant (apo) | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFC | The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to… | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFC | The glic pentameric ligand-gated ion channel F14'A ethanol-sensitive mutant complexed to… | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFD | The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to bromoform | x-ray diffraction | A, B, C, D, E | — | — |
| 4HFD | The glic pentameric ligand-gated ion channel F14'A ethanol-sensitive mutant complexed to bromoform | x-ray diffraction | A, B, C, D, E | — | — |
162 records more on the page itself.
Ligands
- CL · Chloride ion · in 95 records
- NA · Sodium ion · in 76 records
- PLC · Diundecyl phosphatidyl choline · in 61 records
- D12 · Dodecane · in 10 records
- PFL · 2,6-bis(1-methylethyl)phenol · in 10 records
- MBR · Tribromomethane · in 8 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 5 records
- SO4 · Sulfate ion · in 5 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- 2IL · (3R)-3-(dodecanoyloxy)tetradecanoic acid · in 2 records
- 6JA · 2-[5-ethyl-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-yl]ethyl selenocyanate · in 2 records
- 6JW · 5-(2-bromoethyl)-5-ethyl-1,3-diazinane-2,4,6-trione · in 2 records
- A8Z · Tetrahydrodeoxycorticosterone · in 2 records
- BEO · Butenoic acid · in 2 records
- EDP · 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione · in 2 records
- FUM · Fumaric acid · in 2 records
- GUA · Glutaric acid · in 2 records
- PC8 · 1,2-dioctanoyl-sn-glycero-3-phosphocholine · in 2 records
- 6E3 · 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione · in 1 record
- A8W · Pregnenolone sulfate · in 1 record
- BR · Bromide ion · in 1 record
- HXA · Docosa-4,7,10,13,16,19-hexaenoic acid · in 1 record
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 1 record
- XE · Xenon · in 1 record
Experiment against prediction
- 4HFE chain D against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.29 Å
- 4HFE chain D against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.29 Å
- 4HFE chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.29 Å
- 4HFE chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.29 Å
- 6HZ1 chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
- 6HZ1 chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
- 6HZ1 chain D against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
- 6HZ1 chain D against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
- 6HJZ chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
- 6HJZ chain A against the predicted model Q7NDN8: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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