MolNFT v1 · #51897 · protein
X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic)
2VL0 · Cys-loop ligand-gated ion channel: “X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic)”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #51897 on GenesisL1: 3D structure…
- PDB
- 2VL0
- Type
- protein
- Length
- 3,060 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cys-loop ligand-gated ion channel
- UniProt
- P0C7B7
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Cys-loop ligand-gated ion channel | protein | 306 | 25% helix, 31% strand | P0C7B7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 907 | 0.83 | 0.84 | 98 | empty |
| 2 | 888 | 0.82 | 0.84 | 99 | empty |
| 3 | 649 | 0.82 | 0.86 | 49 | empty |
| 4 | 915 | 0.81 | 0.83 | 93 | empty |
| 5 | 655 | 0.81 | 0.86 | 49 | empty |
Interfaces
21 interfaces between chains.
- G–H · 2680 Ų buried · 34 hydrogen bonds · protein-protein
- B–C · 2677 Ų buried · 33 hydrogen bonds · protein-protein
- H–I · 2655 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2652 Ų buried · 31 hydrogen bonds · protein-protein
- F–J · 2647 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 2VL0 · X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) · the same entry in another collection · chain G against G, TM-score 1.00
- P0C7B7 · AlphaFold monomer V2.0 prediction for cys-loop ligand-gated ion channel (P0C7B7) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C7B7
- Elsewhere: RCSB PDB 2VL0 · PDBe 2VL0 · UniProt P0C7B7
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