UniProt P0A776
RNA pyrophosphohydrolase (P0A776)
RNA pyrophosphohydrolase (UniProt P0A776), EC 3.6.1.-: 34 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A776
- Protein
- RNA pyrophosphohydrolase
- EC
- 3.6.1.-
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 20 · 1 record with a druggable one
Structures
35 records of P0A776 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KDV | Solution structure of RNA Pyrophosphohydrolase RppH from Escherichia coli | solution nmr | A | — | — |
| 2KDV | Solution structure of RNA pyrophosphohydrolase rpph from escherichia COLI | solution nmr | A | — | — |
| 2KDW | Solution structure of RppH mutant E53A from Escherichia coli | solution nmr | A | — | — |
| 2KDW | Solution structure of rpph mutant E53A from escherichia COLI | solution nmr | A | — | — |
| 4S2V | E. coli RppH structure, KI soak | x-ray diffraction | A | — | — |
| 4S2V | E. COLI rpph structure, ki soak | x-ray diffraction | A | — | — |
| 4S2W | Structure of E. coli RppH bound to sulfate ions | x-ray diffraction | A | — | — |
| 4S2W | Structure of E. COLI rpph bound to sulfate ions | x-ray diffraction | A | — | — |
| 4S2X | Structure of E. coli RppH bound to RNA and two magnesium ions | x-ray diffraction | A | — | — |
| 4S2X | Structure of E. COLI rpph bound to RNA and two magnesium ions | x-ray diffraction | A | — | — |
| 4S2Y | Structure of E. coli RppH bound to RNA and three magnesium ions | x-ray diffraction | A | — | — |
| 4S2Y | Structure of E. COLI rpph bound to RNA and three magnesium ions | x-ray diffraction | A | — | — |
| 5YGU | Crystal structure of Escherichia coli (strain K12) mRNA Decapping Complex RppH-DapF | x-ray diffraction | B | IOD | 4 (best 0.57) |
| 5YGU | Crystal structure of escherichia COLI (strain K12) mRNA decapping complex rpph-dapf | x-ray diffraction | B | IOD | — |
| 6D1Q | Crystal structure of E. coli RppH-DapF complex, monomer | x-ray diffraction | B | — | — |
| 6D1Q | Crystal structure of E. COLI rpph-dapf complex, monomer | x-ray diffraction | B | — | — |
| 6D1V | Crystal structure of E. coli RppH-DapF complex, monomer bound to RNA | x-ray diffraction | B | MG, CL | 2 (best 0.35) |
| 6D1V | Crystal structure of E. COLI rpph-dapf complex, monomer bound to RNA | x-ray diffraction | B | MG, CL | — |
| 6VCK | Crystal structure of E.coli RppH-DapF in complex with GDP, Mg2+ and F- | x-ray diffraction | B | MG, GDP, CL, F | 2 (best 0.41) |
| 6VCK | Crystal structure of E.COLI rpph-dapf in complex with GDP, MG2+ and F- | x-ray diffraction | B | MG, GDP, CL, F | — |
| 6VCL | Crystal structure of E.coli RppH-DapF in complex with pppGpp, Mg2+ and F- | x-ray diffraction | B | MG, CL, F, 0O2 | 2 (best 0.40) |
| 6VCL | Crystal structure of E.COLI rpph-dapf in complex with pppgpp, MG2+ and F- | x-ray diffraction | B | MG, CL, F, 0O2 | 2 (best 0.40) |
| 6VCM | Crystal structure of E.coli RppH-DapF in complex with GTP, Mg2+ and F- | x-ray diffraction | B | CL, MG, GTP, F | 4 (best 0.49) |
| 6VCM | Crystal structure of E.COLI rpph-dapf in complex with GTP, MG2+ and F- | x-ray diffraction | B | CL, MG, GTP, F | — |
| 6VCN | Crystal structure of E.coli RppH in complex with ppcpG | x-ray diffraction | A | G2P, SO4 | 1 (best 0.37) |
| 6VCN | Crystal structure of E.COLI rpph in complex with ppcpg | x-ray diffraction | A | G2P, SO4 | — |
| 6VCO | Crystal structure of E.coli RppH in complex with ppcpA | x-ray diffraction | A | APC | — |
| 6VCO | Crystal structure of E.COLI rpph in complex with ppcpa | x-ray diffraction | A | APC | — |
| 6VCP | Crystal structure of E.coli RppH in complex with UTP | x-ray diffraction | A | UTP | — |
| 6VCP | Crystal structure of E.COLI rpph in complex with UTP | x-ray diffraction | A | UTP | — |
| 6VCQ | Crystal structure of E.coli RppH in complex with GTP | x-ray diffraction | A | GTP, SO4 | 1 (best 0.31) |
| 6VCQ | Crystal structure of E.COLI rpph in complex with GTP | x-ray diffraction | A | GTP, SO4 | — |
| 6VCR | Crystal structure of E.coli RppH in complex with CTP | x-ray diffraction | A | CTP, PPV, SO4 | 1 (best 0.40) |
| 6VCR | Crystal structure of E.COLI rpph in complex with CTP | x-ray diffraction | A | CTP, PPV, SO4 | — |
| P0A776 | AlphaFold monomer V2.0 prediction for RNA pyrophosphohydrolase (P0A776) | predicted | A | — | 1 (best 0.38) |
Ligands
- CL · Chloride ion · in 8 records
- MG · Magnesium ion · in 8 records
- F · Fluoride ion · in 6 records
- SO4 · Sulfate ion · in 6 records
- GTP · Guanosine-5'-triphosphate · in 4 records
- 0O2 · guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) · in 2 records
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 2 records
- CTP · Cytidine-5'-triphosphate · in 2 records
- G2P · Phosphomethylphosphonic acid guanylate ester · in 2 records
- GDP · Guanosine-5'-diphosphate · in 2 records
- IOD · Iodide ion · in 2 records
- PPV · Pyrophosphate · in 2 records
- UTP · Uridine 5'-triphosphate · in 2 records
Experiment against prediction
- 6D1V chain B against the predicted model P0A776: TM-score 0.99, RMSD 0.43 Å
- 6D1V chain B against the predicted model P0A776: TM-score 0.99, RMSD 0.43 Å
- 4S2Y chain A against the predicted model P0A776: TM-score 0.99, RMSD 0.58 Å
- 4S2Y chain A against the predicted model P0A776: TM-score 0.99, RMSD 0.58 Å
- 6D1Q chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.50 Å
- 6D1Q chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.50 Å
- 6VCL chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.50 Å
- 6VCL chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.50 Å
- 6VCM chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.53 Å
- 6VCM chain B against the predicted model P0A776: TM-score 0.98, RMSD 0.53 Å
Elsewhere
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