UniProt P0A031

Cell division protein FtsZ (P0A031)

Cell division protein FtsZ (UniProt P0A031): 63 experimental structures and 1 predicted model on GenesisL1, 19 ligands bound, 73 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P0A031
Protein: Cell division protein FtsZ
Experimental structures: 63
Predicted models: 1
Ligands: 19
Pockets: 73 · 21 records with a druggable one

Structures

64 records of P0A031 in the MolNFT archive: 63 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4DXD	Staphylococcal Aureus FtsZ in complex with 723	x-ray diffraction	A	—	—
4DXD	Staphylococcal aureus ftsz in complex with 723	x-ray diffraction	A	—	—
5MN4	S. aureus FtsZ 12-316 F138A GDP Open form (1FOf)	x-ray diffraction	A	GDP	—
5MN4	S. aureus ftsz 12-316 F138A GDP open form (1FOF)	x-ray diffraction	A	GDP	—
5MN5	S. aureus FtsZ 12-316 T66W GTP Closed form (2TCm)	x-ray diffraction	A, B	GTP	—
5MN5	S. aureus ftsz 12-316 T66W GTP closed form (2TCM)	x-ray diffraction	A, B	GTP	—
5MN6	S. aureus FtsZ 12-316 F138A GDP Closed form (3FCm)	x-ray diffraction	A, B	GDP	—
5MN6	S. aureus ftsz 12-316 F138A GDP closed form (3FCM)	x-ray diffraction	A, B	GDP	—
5MN7	S. aureus FtsZ 12-316 F138A GTP Closed form (3FCm)	x-ray diffraction	A, B	MG, GTP	—
5MN7	S. aureus ftsz 12-316 F138A GTP closed form (3FCM)	x-ray diffraction	A, B	MG, GTP	—
5MN8	S. aureus FtsZ 12-316 F138A GTP Closed form (5FCm)	x-ray diffraction	B, A	GTP	—
5MN8	S. aureus ftsz 12-316 F138A GTP closed form (5FCM)	x-ray diffraction	B, A	GTP	—
6KVP	S. aureus FtsZ in complex with 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)-2,6-di…	x-ray diffraction	A	GDP, CA, ZI1	3 (best 0.74)
6KVP	S. aureus ftsz in complex with 3-(1-(5-bromo-4-(4-(trifluoromethyl)…	x-ray diffraction	A	GDP, CA, ZI1	—
6KVQ	S. aureus FtsZ in complex with BOFP (compound 3)	x-ray diffraction	A	GDP, CA, DVX	—
6KVQ	S. aureus ftsz in complex with bofp (compound 3)	x-ray diffraction	A	GDP, CA, DVX	—
6RVM	Cell division protein FtsZ from Staphylococcus aureus, apo form	x-ray diffraction	A, B, C, D	SO4, CL, MG	14 (best 0.83)
6RVM	Cell division protein ftsz from staphylococcus aureus, apo form	x-ray diffraction	A, B, C, D	SO4, CL, MG	—
6RVN	aFtsz-GDP-Wat	x-ray diffraction	A	GDP, CA	—
6RVN	Aftsz-GDP-wat	x-ray diffraction	A	GDP, CA	—
6RVP	SaFtsz-GDP-MetPyr	x-ray diffraction	A	GDP, CA, MB3	3 (best 0.62)
6RVP	Saftsz-GDP-metpyr	x-ray diffraction	A	GDP, CA, MB3	—
6RVQ	SaFtsz-GDP-EthGLy	x-ray diffraction	A	GDP, CA	3 (best 0.60)
6RVQ	Saftsz-GDP-ethgly	x-ray diffraction	A	GDP, CA	—
6SI9	FtsZ-refold	x-ray diffraction	A	GDP, CA	3 (best 0.61)
6SI9	FTSZ-REFOLD	x-ray diffraction	A	GDP, CA	—
6YD1	SaFtsZ-DFMBA	x-ray diffraction	A	GDP, OLQ, K	3 (best 0.60)
6YD1	Saftsz-dfmba	x-ray diffraction	A	GDP, OLQ, K	—
6YD5	SaFtsZ-UCM151 (comp. 18)	x-ray diffraction	A	GDP, MB3, K, OM8	—
6YD5	Saftsz-UCM151 (comp. 18)	x-ray diffraction	A	GDP, MB3, K, OM8	—
6YD6	SaFtsZ-UCM152 (comp.20)	x-ray diffraction	A	GDP, OMW, K, MB3	3 (best 0.66)
6YD6	Saftsz-UCM152 (COMP.20)	x-ray diffraction	A	GDP, OMW, K, MB3	—
7OHH	SaFtsZ complexed with GDP and BeF3-	x-ray diffraction	A	GDP, BEF, K	3 (best 0.61)
7OHH	Saftsz complexed with GDP and BEF3-	x-ray diffraction	A	GDP, BEF, K	—
7OHK	SaFtsZ complexed with GDP, BeF3- and Mg2+	x-ray diffraction	A	GDP, BEF, MG, K	3 (best 0.60)
7OHK	Saftsz complexed with GDP, BEF3- and MG2+	x-ray diffraction	A	GDP, BEF, MG, K	—
7OHL	SaFtsZ complexed with GDP, BeF3- and Mn2+	x-ray diffraction	A	GDP, BEF, MN, K	3 (best 0.61)
7OHL	Saftsz complexed with GDP, BEF3- and MN2+	x-ray diffraction	A	GDP, BEF, K	—
7OHN	SaFtsZ complexed with GDP, AlF4- and Mg2+	x-ray diffraction	A	GDP, K, ALF, MG	3 (best 0.59)
7OHN	Saftsz complexed with GDP, ALF4- and MG2+	x-ray diffraction	A	GDP, K, ALF, MG	—
7OI2	SaFtsz complexed with GDP (NaCl purification)	x-ray diffraction	A	GDP, NA	3 (best 0.60)
7OI2	Saftsz complexed with GDP (nacl purification)	x-ray diffraction	A	GDP, NA	—
7OJA	SaFtsZ(D210N) complexed with GDP	x-ray diffraction	A	GDP, SO4	—
7OJA	SAFTSZ(D210N) complexed with GDP	x-ray diffraction	A	GDP, SO4	—
7OJB	SaFtsZ(R143K) complexed with GDP	x-ray diffraction	A	GDP, K	3 (best 0.61)
7OJB	SAFTSZ(R143K) complexed with GDP	x-ray diffraction	A	GDP, K	—
7OJC	SaFtsZ(Q48A) complexed with GDP	x-ray diffraction	A	GDP, K	3 (best 0.59)
7OJC	SAFTSZ(Q48A) complexed with GDP	x-ray diffraction	A	GDP, K	—
7OJD	SAFTSZ(D46A) complexed with GDP	x-ray diffraction	A	GDP, K	—
7OJZ	SaFtsZ complexed with GMPCP	x-ray diffraction	A	GP2, K	3 (best 0.61)
7OJZ	Saftsz complexed with gmpcp	x-ray diffraction	A	GP2, K	—
7OMJ	SaFtsZ complexed with GDPPCP	x-ray diffraction	A	GCP, K	3 (best 0.61)
7OMJ	Saftsz complexed with gdppcp	x-ray diffraction	A	GCP, K	—
7OMP	SaFtsZ complexed with GDPPCP and Mg2+	x-ray diffraction	A	GCP, MG	2 (best 0.60)
7OMP	Saftsz complexed with gdppcp and MG2+	x-ray diffraction	A	GCP	—
7OMQ	SaFtsZ complexed with GDPPCP and Mn2+	x-ray diffraction	A	GCP, MN	3 (best 0.60)
7OMQ	Saftsz complexed with gdppcp and MN2+	x-ray diffraction	A	GCP	—
7ON2	SaFtsZ complexed with GDP (soaking in 10 mM CyDTA)	x-ray diffraction	A	GDP, K	3 (best 0.62)
7ON2	Saftsz complexed with GDP (soaking in 10 mm cydta)	x-ray diffraction	A	GDP, K	—
7ON3	SaFtsZ complexed with GDP (soak 10 mM EGTA)	x-ray diffraction	A	GDP, K	3 (best 0.59)

4 records more on the page itself.

Ligands

GDP · Guanosine-5'-diphosphate · in 45 records
K · Potassium ion · in 29 records
CA · Calcium ion · in 12 records
MG · Magnesium ion · in 9 records
BEF · Beryllium trifluoride ion · in 6 records
GCP · Phosphomethylphosphonic acid guanylate ester · in 6 records
GTP · Guanosine-5'-triphosphate · in 6 records
MB3 · 1-methylpyrrolidin-2-one · in 6 records
SO4 · Sulfate ion · in 4 records
ALF · Tetrafluoroaluminate ion · in 2 records
CL · Chloride ion · in 2 records
DVX · [(2R)-2-[3-aminocarbonyl-2,4-bis(fluoranyl)phenoxy]-2-[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]ethyl] 3-[2,2-bis(fluoranyl)-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.0^{3,7}]dodeca-1(12),4,6,8,10-pentaen-4-yl]propanoate · in 2 records
GP2 · Phosphomethylphosphonic acid guanosyl ester · in 2 records
MN · Manganese (II) ion · in 2 records
NA · Sodium ion · in 2 records
OLQ · 2,6-difluoro-3-methoxybenzamide · in 2 records
OM8 · 3-[(3-chlorophenyl)methoxy]-2,6-bis(fluoranyl)benzamide · in 2 records
OMW · 2,6-bis(fluoranyl)-3-[[3-(trifluoromethyl) phenyl]methoxy]benzamide · in 2 records
ZI1 · 3-[(1R)-1-[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1, 3-oxazol-2-yl]ethoxy]-2,6-bis(fluoranyl)benzamide · in 2 records

Experiment against prediction

5MN5 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.62 Å
5MN5 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.62 Å
5MN8 chain A against the predicted model P0A031: TM-score 0.99, RMSD 0.71 Å
5MN8 chain A against the predicted model P0A031: TM-score 0.99, RMSD 0.71 Å
5MN8 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.71 Å
5MN8 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.71 Å
5MN6 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.80 Å
5MN6 chain B against the predicted model P0A031: TM-score 0.99, RMSD 0.80 Å
5MN6 chain A against the predicted model P0A031: TM-score 0.98, RMSD 0.92 Å
5MN6 chain A against the predicted model P0A031: TM-score 0.98, RMSD 0.92 Å

Elsewhere

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