MolNFT v1 · #127122 · protein
S. aureus ftsz 12-316 F138A GTP closed form (5FCM)
5MN8 · Cell division protein ftsz: “S. aureus ftsz 12-316 F138A GTP closed form (5FCM)”. X-ray diffraction, 1 ligand (GTP), 6 pockets (best druggability 0.71). MolNFT v1 #127122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MN8
- Type
- protein
- Length
- 598 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein ftsz
- UniProt
- P0A031
- Ligands
- GTP
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Cell division protein ftsz | protein | 299 | 43% helix, 23% strand | P0A031 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 672 | 0.71 | 0.79 | 57 | empty |
| 2 | 238 | 0.56 | 0.78 | 28 | empty |
| 3 | 190 | 0.52 | 0.78 | 33 | GTP |
| 4 | 139 | 0.52 | 0.80 | 26 | empty |
| 5 | 184 | 0.50 | 0.78 | 33 | GTP |
Interfaces
1 interface between chains.
- B–A · 375 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A031
- Elsewhere: RCSB PDB 5MN8 · PDBe 5MN8 · UniProt P0A031
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