S. aureus ftsz in complex with bofp (compound 3)

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 24% strand (DSSP).

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · chains A
• DVX · [(2R)-2-[3-aminocarbonyl-2,4-bis(fluoranyl)phenoxy]-2-[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]ethyl] 3-[2,2-bis(fluoranyl)-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.0^{3,7}]dodeca-1(12),4,6,8,10-pentaen-4-yl]propanoate · ligand · chains A
• CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 6KVQ · S. aureus FtsZ in complex with BOFP (compound 3) · the same entry in another collection · chain A against A, TM-score 1.00
• P0A031 · AlphaFold monomer V2.0 prediction for cell division protein ftsz (P0A031) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0A031
• Elsewhere: RCSB PDB 6KVQ · PDBe 6KVQ · UniProt P0A031