UniProt P06746
DNA polymerase beta (P06746)
DNA polymerase beta (UniProt P06746), EC 2.7.7.7, 4.2.99.-: 686 experimental structures and 1 predicted model on GenesisL1, 78 ligands bound, 301 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P06746
- Protein
- DNA polymerase beta
- EC
- 2.7.7.7, 4.2.99.-
- Experimental structures
- 686
- Predicted models
- 1
- Ligands
- 78
- Pockets
- 301 · 96 records with a druggable one
Structures
687 records of P06746 in the MolNFT archive: 686 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BPX | DNA polymerase BETA/DNA complex | x-ray diffraction | A | — | — |
| 1BPX | DNA polymerase BETA/DNA complex | x-ray diffraction | A | — | — |
| 1BPY | Human DNA polymerase beta complexed with gapped DNA and ddctp | x-ray diffraction | A | — | — |
| 1BPY | Human DNA polymerase beta complexed with gapped DNA and ddctp | x-ray diffraction | A | — | — |
| 1BPZ | Human DNA polymerase beta complexed with nicked DNA | x-ray diffraction | A | — | — |
| 1BPZ | Human DNA polymerase beta complexed with nicked DNA | x-ray diffraction | A | — | — |
| 1MQ2 | Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP | x-ray diffraction | A | — | — |
| 1MQ2 | Human DNA polymerase beta complexed with gapped DNA containing an 8-oxo-7,8-dihydro-guanine and damp | x-ray diffraction | A | — | — |
| 1MQ3 | Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine… | x-ray diffraction | A | — | — |
| 1MQ3 | Human DNA polymerase beta complexed with gapped DNA containing an 8-oxo-7,8-dihydro-guanine… | x-ray diffraction | A | — | — |
| 1TV9 | Human DNA polymerase beta complexed with nicked DNA containing a mismatched template adenine and… | x-ray diffraction | A | — | — |
| 1TV9 | Human DNA polymerase beta complexed with nicked DNA containing a mismatched template adenine and… | x-ray diffraction | A | — | — |
| 1TVA | Human DNA polymerase beta complexed with nicked DNA containing a mismatched template thymidine and… | x-ray diffraction | A | — | — |
| 1TVA | Human DNA polymerase beta complexed with nicked DNA containing a mismatched template thymidine and… | x-ray diffraction | A | — | — |
| 1ZJM | Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus | x-ray diffraction | A | — | — |
| 1ZJM | Human DNA polymerase beta complexed with DNA containing an a-a mismatched primer terminus | x-ray diffraction | A | — | — |
| 1ZJN | Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus with dGTP | x-ray diffraction | A | — | — |
| 1ZJN | Human DNA polymerase beta complexed with DNA containing an a-a mismatched primer terminus with dgtp | x-ray diffraction | A | — | — |
| 1ZQA | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQA | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQB | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQB | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQC | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQC | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQD | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQD | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQE | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQE | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQF | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQF | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQG | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQG | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQH | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQH | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQI | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQI | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQJ | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQJ | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQK | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQK | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQL | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQL | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQM | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQM | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQN | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQN | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQO | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQO | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQP | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQP | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQQ | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQQ | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQR | DNA polymerase beta (E.C.2.7.7.7)/DNA complex, soaked in the presence of NICL2 | x-ray diffraction | A | — | — |
| 1ZQR | DNA polymerase beta (E.C.2.7.7.7)/DNA complex, soaked in the presence of NICL2 | x-ray diffraction | A | — | — |
| 1ZQS | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQS | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQT | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 1ZQT | DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked in the… | x-ray diffraction | A | — | — |
| 2FMP | DNA Polymerase beta with a terminated gapped DNA substrate and ddCTP with sodium in the catalytic… | x-ray diffraction | A | — | — |
| 2FMP | DNA polymerase beta with a terminated gapped DNA substrate and ddctp with sodium in the catalytic… | x-ray diffraction | A | — | — |
627 records more on the page itself.
Ligands
- NA · Sodium ion · in 290 records
- MG · Magnesium ion · in 114 records
- CL · Chloride ion · in 83 records
- MN · Manganese (II) ion · in 48 records
- CA · Calcium ion · in 31 records
- PPV · Pyrophosphate · in 22 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 21 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 21 records
- QPJ · 2-deoxy-3,5-di-O-phosphono-D-erythro-pentitol · in 16 records
- DC · 2'-deoxycytidine-5'-monophosphate · in 13 records
- ZN · Zinc ion · in 13 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 11 records
- DUP · 2'-deoxyuridine 5'-alpha,beta-imido-triphosphate · in 11 records
- SO4 · Sulfate ion · in 10 records
- TTP · Thymidine-5'-triphosphate · in 9 records
- 0KX · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]cytidine · in 8 records
- GKS · 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol · in 7 records
- 1RZ · Lamivudine Triphosphate · in 5 records
- DZ4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine · in 5 records
- GFH · 2'-deoxy-5'-O-[(R)-{[(R)-[(R)-fluoro(phosphono) methyl](hydroxy)phosphoryl]oxy}(hydroxy) phosphoryl]guanosine · in 5 records
- XG4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine · in 5 records
- 2PN · Imidodiphosphoric acid · in 4 records
- CD · Cadmium ion · in 4 records
- 1FZ · 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine · in 3 records
- 1GC · 2'-deoxy-5'-O-[(R)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]guanosine · in 3 records
- 42E · [(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate · in 3 records
- 8CP · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonoamino) phosphoryl]oxy}phosphoryl]cytidine · in 3 records
- DCT · 2',3'-dideoxycytidine 5'-triphosphate · in 3 records
- DJJ · 5'-O-[(R)-{[(R)-[(S)-chloro(phosphono)methyl](hydroxy) phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxycytidine · in 3 records
- F3C · 2'-deoxy-5'-O-[(R)-{[(R)-[(R)-fluoro(phosphono) methyl](hydroxy)phosphoryl]oxy}(hydroxy) phosphoryl]cytidine · in 3 records
Experiment against prediction
- 6U6B chain A against the predicted model P06746: TM-score 0.97, RMSD 1.10 Å
- 5BPC chain A against the predicted model P06746: TM-score 0.96, RMSD 1.29 Å
- 4GXK chain A against the predicted model P06746: TM-score 0.96, RMSD 1.32 Å
- 4GXK chain A against the predicted model P06746: TM-score 0.96, RMSD 1.32 Å
- 3ISD chain A against the predicted model P06746: TM-score 0.96, RMSD 1.39 Å
- 3ISD chain A against the predicted model P06746: TM-score 0.96, RMSD 1.39 Å
- 4F5Q chain A against the predicted model P06746: TM-score 0.96, RMSD 1.37 Å
- 4F5Q chain A against the predicted model P06746: TM-score 0.96, RMSD 1.37 Å
- 4KLT chain A against the predicted model P06746: TM-score 0.96, RMSD 1.37 Å
- 4KLT chain A against the predicted model P06746: TM-score 0.96, RMSD 1.37 Å
Elsewhere
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