UniProt P06730
Eukaryotic translation initiation factor 4E (P06730)
Eukaryotic translation initiation factor 4E (UniProt P06730): 74 experimental structures on GenesisL1, 16 ligands bound, 30 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P06730
- Protein
- Eukaryotic translation initiation factor 4E
- Experimental structures
- 74
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 30 · 4 records with a druggable one
Structures
74 records of P06730 in the MolNFT archive: 74 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IPB | Crystal structure of eukaryotic initiation factor 4E complexed with 7-methyl gpppa | x-ray diffraction | A | — | — |
| 1IPB | Crystal structure of eukaryotic initiation factor 4E complexed with 7- methyl gpppa | x-ray diffraction | A | — | — |
| 1IPC | Crystal structure of eukaryotic initiation factor 4E complexed with 7-methyl GTP | x-ray diffraction | A | — | — |
| 1IPC | Crystal structure of eukaryotic initiation factor 4E complexed with 7- methyl GTP | x-ray diffraction | A | — | — |
| 1WKW | Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide | x-ray diffraction | A | — | — |
| 1WKW | Crystal structure of the ternary complex of EIF4E-M7GPPPA-4EBP1 peptide | x-ray diffraction | A | — | — |
| 2GPQ | Cap-free structure of eIF4E suggests basis for its allosteric regulation | solution nmr | A | — | — |
| 2GPQ | Cap-free structure of EIF4E suggests basis for its allosteric regulation | solution nmr | A | — | — |
| 2V8W | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2V8W | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2V8X | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2V8X | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2V8Y | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2V8Y | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | A, E | — | — |
| 2W97 | Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide | x-ray diffraction | A, B | — | — |
| 2W97 | Crystal structure of EIF4E bound to glycerol and EIF4G1 peptide | x-ray diffraction | A, B | — | — |
| 3AM7 | Crystal structure of the ternary complex of eIF4E-M7GTP-4EBP2 peptide | x-ray diffraction | A | — | — |
| 3AM7 | Crystal structure of the ternary complex of EIF4E-M7GTP-4EBP2 peptide | x-ray diffraction | A | — | — |
| 3TF2 | Crystal structure of the cap free human translation initiation factor eIF4E | x-ray diffraction | A, B, C, D | — | — |
| 3TF2 | Crystal structure of the cap free human translation initiation factor EIF4E | x-ray diffraction | A, B, C, D | — | — |
| 3U7X | Crystal structure of the human eIF4E-4EBP1 peptide complex without cap | x-ray diffraction | A, B | — | — |
| 3U7X | Crystal structure of the human EIF4E-4EBP1 peptide complex without cap | x-ray diffraction | A, B | — | — |
| 4AZA | Improved eIF4E binding peptides by phage display guided design. | x-ray diffraction | A, C | — | — |
| 4AZA | Improved EIF4E binding peptides by phage display guided design. | x-ray diffraction | A, C | — | — |
| 4BEA | Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative | x-ray diffraction | A | — | — |
| 4BEA | Crystal structure of EIF4E in complex with a stapled peptide derivative | x-ray diffraction | A | — | — |
| 4DT6 | Co-crystal structure of eIF4E with inhibitor | x-ray diffraction | A | — | — |
| 4DT6 | Co-crystal structure of EIF4E with inhibitor | x-ray diffraction | A | — | — |
| 4DUM | Co-crystal structure of eIF4E with inhibitor | x-ray diffraction | A | — | — |
| 4DUM | Co-crystal structure of EIF4E with inhibitor | x-ray diffraction | A | — | — |
| 4TPW | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4TPW | The co-complex structure of the translation initiation factor EIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4TQB | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4TQB | The co-complex structure of the translation initiation factor EIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4TQC | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4TQC | The co-complex structure of the translation initiation factor EIF4E with the inhibitor 4EGI-1… | x-ray diffraction | A, B | — | — |
| 4UED | Complex of human eIF4E with the 4E binding protein 4E-BP1 | x-ray diffraction | A | — | — |
| 4UED | Complex of human EIF4E with the 4E binding protein 4E-BP1 | x-ray diffraction | A | — | — |
| 5EHC | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | 5NX | — |
| 5EHC | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | — | — |
| 5EI3 | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | 5O8, SO4 | — |
| 5EI3 | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | — | — |
| 5EIR | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | 5O8, SO4 | 1 (best 0.46) |
| 5EIR | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A | — | — |
| 5EKV | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A, C | 5PQ | 3 (best 0.48) |
| 5EKV | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | A, C | — | — |
| 5GW6 | Water-Bridge Mediates Recognition of mRNA Cap in eIF4E | x-ray diffraction | A | — | — |
| 5GW6 | Water-bridge mediates recognition of mRNA cap in EIF4E | x-ray diffraction | A | — | — |
| 5T46 | Crystal structure of the human eIF4E-eIF4G complex | x-ray diffraction | A, C | MGP | 5 (best 0.75) |
| 5T46 | Crystal structure of the human EIF4E-EIF4G complex | x-ray diffraction | A, C | MGP | — |
| 5ZJY | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGP | — |
| 5ZJY | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGP | — |
| 5ZJZ | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGT | 1 (best 0.45) |
| 5ZJZ | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | ACE, MGT | — |
| 5ZK5 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGT | 1 (best 0.41) |
| 5ZK5 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGT | — |
| 5ZK7 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A, B | MGT, IOD, CL | — |
| 5ZK7 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A, B | ACE, NH2, MGT, IOD, CL | — |
| 5ZK9 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGP | 1 (best 0.47) |
| 5ZK9 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | A | MGP | — |
14 records more on the page itself.
Ligands
- MGP · 7-methyl-guanosine-5'-triphosphate · in 8 records
- MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · in 6 records
- MGO · [[(2R,3S,4R,5R)-5-(6-amino-3-methyl-4-oxo-5H-imidazo[4, 5-c]pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate · in 3 records
- 5O8 · ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide · in 2 records
- ACE · Acetyl group · in 2 records
- CL · Chloride ion · in 2 records
- IOD · Iodide ion · in 2 records
- NA · Sodium ion · in 2 records
- NO3 · Nitrate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- Z5D · (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid · in 2 records
- 5NX · 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione · in 1 record
- 5PQ · 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione · in 1 record
- M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · in 1 record
- NH2 · Amino group · in 1 record
- WXL · [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid · in 1 record
Elsewhere
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