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Ligand · MGO

MGO · [[(2R,3S,4R,5R)-5-(6-amino-3-methyl-4-oxo-5H-imidazo[4, 5-c]pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

MGO, [[(2R,3S,4R,5R)-5-(6-amino-3-methyl-4-oxo-5H-imidazo[4, 5-c]pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (C12 H20 N4 O14 P3 +1, 537.2 g/mol), in the MolNFT structures on GenesisL1…

Component
MGO
Formula
C12 H20 N4 O14 P3 +1
Class
ligand
Structures
10
PDB entries
5

Binding sites

MGO in 10 structures; the first of them:

  • 2V8W · Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives · MGO A1218 · binds TRP56, MET101, TRP102, GLU103, ARG112, ASN155, ARG157, LYS159 and 2 more
  • 2W97 · Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide · MGO A1218 · binds TRP56, ASP90, PRO100, MET101, TRP102, GLU103, ARG112, ASN155 and 7 more
  • 4AZA · Improved eIF4E binding peptides by phage display guided design. · MGO A1218 · binds TRP56, GLN57, ASP90, PRO100, MET101, TRP102, GLU103, ASN155 and 7 more
  • 7D6Y · eIF4E in Complex with a Disulphide-Free Autonomous VH Domain · MGO A301 · binds TRP56, PRO100, MET101, TRP102, GLU103, ASN155, ARG157, LYS159 and 2 more
  • 7XTP · eIF4E in Complex with a Disulphide-Free Autonomous VH Domain · MGO A301 · binds TRP56, GLN57, PRO100, MET101, TRP102, GLU103, ASN155, ARG157 and 2 more
  • 2V8W · Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives · MGO A1218 · binds TRP56, MET101, TRP102, GLU103, ARG112, ASN155, ARG157, LYS159 and 2 more
  • 2W97 · Crystal structure of EIF4E bound to glycerol and EIF4G1 peptide · MGO A1218 · binds TRP56, ASP90, PRO100, MET101, TRP102, GLU103, ARG112, ASN155 and 7 more
  • 4AZA · Improved EIF4E binding peptides by phage display guided design. · MGO A1218 · binds TRP56, GLN57, ASP90, PRO100, MET101, TRP102, GLU103, ASN155 and 7 more
  • 7D6Y · EIF4E in complex with a disulphide-free autonomous vh domain · MGO A301 · binds TRP56, PRO100, MET101, TRP102, GLU103, ASN155, ARG157, LYS159 and 2 more
  • 7XTP · EIF4E in complex with a disulphide-free autonomous vh domain · MGO A301 · binds TRP56, GLN57, PRO100, MET101, TRP102, GLU103, ASN155, ARG157 and 2 more

Residues it binds most

TRP 16, LYS 16, ARG 16, GLU 16, ASN 16, MET 16, PRO 12, GLN 10, ASP 6, GLY 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • PGE · Triethylene glycol
  • ACE · Acetyl group
  • NH2 · Amino group

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