MolNFT v1 · #38187 · protein

Cap-free structure of EIF4E suggests basis for its allosteric regulation

2GPQ · Eukaryotic translation initiation factor 4E: “Cap-free structure of EIF4E suggests basis for its allosteric regulation”. Solution nmr, 5 pockets (best druggability 0.73). MolNFT v1 #38187 on GenesisL1: 3D structure, binding sites…

PDB: 2GPQ
Type: protein
Length: 217 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E
UniProt: P06730
Pockets: 5 · best druggability 0.73

Structure

solution nmr · 1 distinct chain · 29% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E	protein	217	29% helix, 27% strand	P06730

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.73	0.90	30	empty
2	97	0.55	0.84	19	empty
3	203	0.50	0.76	21	empty
4	59	0.35	0.78	15	empty
5	55	0.25	0.73	13	empty

Compared structures

2GPQ · Cap-free structure of eIF4E suggests basis for its allosteric regulation · the same entry in another collection · chain A against A, TM-score 1.00
P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06730
Elsewhere: RCSB PDB 2GPQ · PDBe 2GPQ · UniProt P06730

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