MolNFT v1 · #26299 · protein
Crystal structure of the ternary complex of EIF4E-M7GPPPA-4EBP1 peptide
1WKW · Eukaryotic translation initiation factor 4E: “Crystal structure of the ternary complex of EIF4E-M7GPPPA-4EBP1 peptide”. X-ray diffraction, 1 ligand (GTA), 1 pocket (best druggability 0.50). MolNFT v1 #26299 on GenesisL1: 3D…
- PDB
- 1WKW
- Type
- protein
- Length
- 211 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Eukaryotic translation initiation factor 4E…
- UniProt
- P06730, Q13541
- Ligands
- GTA
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 191 | 31% helix, 26% strand | P06730 |
| B | Eukaryotic translation initiation factor 4E binding protein 1 | protein | 20 | 30% helix, 0% strand | Q13541 |
Ligands and binding sites
- GTA · P1-7-methylguanosine-P3-adenosine-5',5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 189 | 0.50 | 0.77 | 27 | GTA |
Interfaces
1 interface between chains.
- A–B · 738 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 1WKW · Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q13541 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06730
- Every structure of UniProt Q13541
- Elsewhere: RCSB PDB 1WKW · PDBe 1WKW · UniProt P06730 · UniProt Q13541
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