UniProt Q13541
Eukaryotic translation initiation factor 4E-binding protein 1 (Q13541)
Eukaryotic translation initiation factor 4E-binding protein 1 (UniProt Q13541): 35 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q13541
- Protein
- Eukaryotic translation initiation factor 4E-binding protein 1
- Experimental structures
- 35
- Predicted models
- 1
- Pockets
- 6 · 3 records with a druggable one
Structures
36 records of Q13541 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WKW | Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide | x-ray diffraction | B | — | — |
| 1WKW | Crystal structure of the ternary complex of EIF4E-M7GPPPA-4EBP1 peptide | x-ray diffraction | B | — | — |
| 2JGB | Structure of human eIF4E homologous protein 4EHP with m7GTP | x-ray diffraction | B | — | — |
| 2JGB | Structure of human EIF4E homologous protein 4EHP with M7GTP | x-ray diffraction | B | — | — |
| 2JGC | Structure of the human eIF4E homologous protein, 4EHP without ligand bound | x-ray diffraction | B | — | — |
| 2JGC | Structure of the human EIF4E homologous protein, 4EHP without ligand bound | x-ray diffraction | B | — | — |
| 2V8W | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 2V8W | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 2V8X | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 2V8X | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 2V8Y | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 2V8Y | Crystallographic and mass spectrometric characterisation of EIF4E with N7-cap derivatives | x-ray diffraction | B, F | — | — |
| 3HXG | Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP | x-ray diffraction | C | — | — |
| 3HXG | Crystal structure of schistsome EIF4E complexed with M7GPPPA and 4E-bp | x-ray diffraction | C | — | — |
| 3HXI | Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP | x-ray diffraction | C | — | — |
| 3HXI | Crystal structure of schistosome EIF4E complexed with M7GPPPG and 4E-bp | x-ray diffraction | C | — | — |
| 3M93 | Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap | x-ray diffraction | C | — | — |
| 3M93 | Complex crystal structure of ascaris suum EIF4E-3 with M7G cap | x-ray diffraction | C | — | — |
| 3M94 | Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap | x-ray diffraction | C | — | — |
| 3M94 | Complex crystal structure of ascaris suum EIF4E-3 with M2,2,7G cap | x-ray diffraction | C | — | — |
| 3U7X | Crystal structure of the human eIF4E-4EBP1 peptide complex without cap | x-ray diffraction | C, D | — | — |
| 3U7X | Crystal structure of the human EIF4E-4EBP1 peptide complex without cap | x-ray diffraction | C, D | — | — |
| 4UED | Complex of human eIF4E with the 4E binding protein 4E-BP1 | x-ray diffraction | B | — | — |
| 4UED | Complex of human EIF4E with the 4E binding protein 4E-BP1 | x-ray diffraction | B | — | — |
| 5BXV | eIF4E complex | x-ray diffraction | B, D | — | 2 (best 0.72) |
| 5BXV | EIF4E complex | x-ray diffraction | B, D | — | — |
| 5EKV | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | B, D | — | 1 (best 0.43) |
| 5EKV | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | B, D | — | — |
| 5NVN | Crystal structure of the human 4EHP-4E-BP1 complex | x-ray diffraction | B, D | — | — |
| 5NVN | Crystal structure of the human 4EHP-4E-BP1 complex | x-ray diffraction | B, D | — | — |
| 5WBJ | Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 | x-ray diffraction | T | — | — |
| 5WBJ | Crystal structure of the arabidopsis thaliana raptor in complex with the tos peptide of human 4EBP1 | x-ray diffraction | T | — | — |
| 8RCH | CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in… | electron microscopy | Z, X | — | — |
| 8RCK | CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in… | electron microscopy | X | — | 2 (best 0.70) |
| 8RCN | CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in… | electron microscopy | X | — | 1 (best 0.63) |
| Q13541 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding protein 1… | predicted | A | — | — |
Experiment against prediction
- 4UED chain B against the predicted model Q13541: TM-score 0.87, RMSD 0.91 Å
- 4UED chain B against the predicted model Q13541: TM-score 0.87, RMSD 0.91 Å
- 5NVN chain D against the predicted model Q13541: TM-score 0.86, RMSD 0.86 Å
- 5NVN chain D against the predicted model Q13541: TM-score 0.86, RMSD 0.86 Å
- 5NVN chain B against the predicted model Q13541: TM-score 0.85, RMSD 0.88 Å
- 5NVN chain B against the predicted model Q13541: TM-score 0.85, RMSD 0.88 Å
- 5BXV chain D against the predicted model Q13541: TM-score 0.85, RMSD 0.79 Å
- 5BXV chain D against the predicted model Q13541: TM-score 0.85, RMSD 0.79 Å
- 5BXV chain B against the predicted model Q13541: TM-score 0.85, RMSD 1.49 Å
- 5BXV chain B against the predicted model Q13541: TM-score 0.85, RMSD 1.49 Å
Elsewhere
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