Ligand · MGP
MGP · 7-methyl-guanosine-5'-triphosphate
MGP, 7-methyl-guanosine-5'-triphosphate (C11 H19 N5 O14 P3 +1, 538.2 g/mol), in the MolNFT structures on GenesisL1: bound in 37 records (23 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…
- Component
- MGP
- Formula
- C11 H19 N5 O14 P3 +1
- Class
- ligand
- Structures
- 37
- PDB entries
- 23
Binding sites
MGP in 37 structures; the first of them:
- 5BXV · eIF4E complex · MGP A301 · binds TRP56, PRO100, MET101, TRP102, GLU103, ASN155, ARG157, LYS162 and 1 more
- 5T46 · Crystal structure of the human eIF4E-eIF4G complex · MGP A301 · binds TRP56, PRO100, MET101, TRP102, GLU103, ASN155, ARG157, LYS162 and 2 more
- 5TFB · Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance… · MGP A702 · binds TRP401, VAL440, SER459, THR460, GLY461, ALA462, GLY463, LYS464 and 4 more
- 5ZJY · Stapled-peptides tailored against initiation of translation · MGP A1001 · binds TRP56, MET101, TRP102, GLU103, ARG157, LYS162
- 5ZK9 · Stapled-peptides tailored against initiation of translation · MGP A1001 · binds TRP56, ASP90, PRO100, MET101, TRP102, GLU103, ASN155, ARG157 and 2 more
- 6EVK · Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap… · MGP C901 · binds PHE323, SER324, PHE325, ARG332, SER337, ARG339, THR355, PHE357 and 8 more
- 6FBZ · Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum in the… · MGP A301 · binds PRO112, GLU113, TRP114, GLU115, ASN167, ARG169, PHE172, ARG174 and 1 more
- 6FC1 · Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the… · MGP A301 · binds TRP58, LYS90, PRO102, GLU103, TRP104, GLU105, LYS114, ARG157 and 2 more
- 6WVN · Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and… · MGP A7114 · binds ASN6811, THR6854, LEU6855, THR6856, ALA6986, TRP6987, CYS7007, ASN7008 and 1 more
- 7FGG · Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GTP · MGP A1003 · binds ASN35, HIS37, ALA40, ARG41, ARG70, ARG92, ASP152, TYR154 and 7 more
- 7JHE · Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with… · MGP A7104 · binds THR56, LEU57, THR58, ALA188, TRP189, CYS209, ASN210, SER276
- 7JIB · Room Temperature Crystal Structure of Nsp10/Nsp16 from SARS-CoV-2 with Substrates and… · MGP A7107 · binds ASN13, LEU57, THR58, ALA188, TRP189, CYS209, ASN210, SER276
- 7MEU · A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of… · MGP A1000 · binds TRP56, ASP90, PRO100, MET101, TRP102, GLU103, ASN155, ARG157 and 4 more
- 7V1H · Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and… · MGP A401 · binds LYS13, LEU16, ASN17, ASN18, CYS19, LYS21, PHE24, ARG28 and 6 more
- 7V1I · Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with an m7GMP-Arg28 adduct… · MGP A303 · binds LYS13, LEU16, ASN17, ASN18, CYS19, PHE24, ARG28, SER150 and 5 more
- 8AOW · CryoEM structure of the Chikungunya virus nsP1 capping pores in complex with m7GTP and… · MGP A1003 · binds ASN35, HIS37, ALA40, ARG41, ARG70, ARG92, ASP152, TYR154 and 8 more
Residues it binds most
ARG 70, TYR 42, GLU 66, TRP 36, PHE 48, ASN 51, ALA 50, ASP 44, LYS 31, VAL 42 (residue and the binding sites it lines).
Found with
- ZN · Zinc ion
- GOL · Glycerol
- MG · Magnesium ion
- CL · Chloride ion
- GTA · P1-7-methylguanosine-P3-adenosine-5',5'-triphosphate
- SAH · S-adenosyl-L-homocysteine
- V9G · 7-methyl-guanosine-5'-triphosphate-5'-(2'-O-methyl)-adenosine
- SO4 · Sulfate ion
- PEG · Di(hydroxyethyl)ether
- ACE · Acetyl group
- ADE · Adenine
- SAM · S-adenosylmethionine
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