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Ligand · V9G

V9G · 7-methyl-guanosine-5'-triphosphate-5'-(2'-O-methyl)-adenosine

V9G, 7-methyl-guanosine-5'-triphosphate-5'-(2'-O-methyl)-adenosine (C22 H32 N10 O17 P3, 801.5 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
V9G
Formula
C22 H32 N10 O17 P3
Class
ligand
Structures
5
PDB entries
4

Binding sites

V9G in 5 structures; the first of them:

  • 7JIB · Room Temperature Crystal Structure of Nsp10/Nsp16 from SARS-CoV-2 with Substrates and… · V9G A7106 · binds CYS25, ASP26, LEU27, TYR30, LYS46, TYR132, PRO134, LYS137 and 11 more
  • 9EMV · SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA… · V9G A7211 · binds LYS6822, CYS6823, ASP6824, LEU6825, TYR6828, ASN6841, LYS6844, ASP6928 and 14 more
  • 7JHE · Room temperature structure of SARS-cov-2 NSP10/NSP16 methyltransferase in a complex with… · V9G A7103 · binds CYS25, ASP26, LEU27, TYR30, ASN43, LYS46, TYR132, PRO134 and 11 more
  • 7JIB · Room temperature crystal structure of NSP10/NSP16 from SARS-cov-2 with substrates and… · V9G A7106 · binds CYS25, ASP26, LEU27, TYR30, LYS46, TYR132, PRO134, LYS137 and 11 more
  • 7V1E · Crystal structure of omsk hemorrhagic fever virus NS5 mtase (in complex with sah and… · V9G A303 · binds LYS13, LEU16, ASN17, CYS19, LYS21, PHE24, ARG28, SER150 and 3 more

Residues it binds most

LYS 5, SER 5, GLU 4, TYR 4, ASN 5, ASP 4, CYS 5, LEU 5, PRO 5, THR 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • GTA · P1-7-methylguanosine-P3-adenosine-5',5'-triphosphate
  • MGP · 7-methyl-guanosine-5'-triphosphate
  • CL · Chloride ion
  • 5GP · Guanosine-5'-monophosphate
  • SAH · S-adenosyl-L-homocysteine
  • SGV · Sangivamycin
  • EDO · 1,2-ethanediol
  • GOL · Glycerol
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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