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Ligand · 5GP

5GP · Guanosine-5'-monophosphate

5GP, Guanosine-5'-monophosphate (C10 H14 N5 O8 P, 363.2 g/mol), in the MolNFT structures on GenesisL1: bound in 66 records (53 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
5GP
Formula
C10 H14 N5 O8 P
Class
ligand
Structures
66
PDB entries
53

Binding sites

5GP in 66 structures; the first of them:

  • 4XBA · Hnt3 · 5GP B301 · binds ASN37, LEU38, TYR41, ASN50, VAL61, ARG62, ASP63, MET64 and 10 more
  • 5DHC · Cooperativity and Downstream Binding in RNA Replication · 5GP A104 · binds LCC1, LCC2, LCA3, U14
  • 5ESX · Crystal structure of hypoxanthine-guanine phosphoribosyltransferase complexed with GMP… · 5GP A600 · binds ARG76, ASP105, ASP106, ILE107, ASP109, GLY110, GLY111, ILE112 and 6 more
  • 5K1D · Crystal structure of a class C beta lactamase/compound1 complex · 5GP A401 · binds SER65, LEU120, GLN121, TYR151, ILE292, LEU293, LYS312, THR313 and 4 more
  • 5KM1 · Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) GMP catalytic product complex · 5GP A201 · binds ILE18, PHE19, ILE22, PHE41, HIS42, ASP43, ILE44, SER45 and 10 more
  • 5O7F · Structure of the inactive T.maritima PDE (TM1595) D80N D154N mutant with GMP and Mn2+ · 5GP A401 · binds SER82, ARG86, HIS105, HIS263, SER265, ARG267, GLY283, GLY284 and 7 more
  • 5Y62 · YfiR complexed with GMP · 5GP B600 · binds ARG60, ARG175, HIS177
  • 5YG6 · Crystal structure of ribose-1,5-bisphosphate isomerase mutant C135S from Pyrococcus… · 5GP A404 · binds PRO258, GLU264, LEU267, ARG268, TRP270, PRO271, ILE274, GLU275 and 1 more
  • 5YGA · Crystal structure of ribose-1,5-bisphosphate isomerase mutant D204N from Pyrococcus… · 5GP B404 · binds ASP257, PRO258, THR259, GLU264, LEU267, ARG268, TRP270, PRO271 and 4 more
  • 6AEK · Crystal structure of ENPP1 in complex with pApG · 5GP A1008 · binds LYS237, ASN259, LEU272, HIS362, SER514, GLY515, PHE516, HIS517
  • 6GAW · Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.… · 5GP BA3203 · binds C1235, C1236, G1245, A1246, A1255
  • 6J23 · Crystal structure of arabidopsis ADAL complexed with GMP · 5GP A401 · binds HIS15, LEU16, ASN17, PHE58, PHE61, HIS65, THR97, THR98 and 9 more
  • 6LOW · crystal structure of alpha-momorcharin in complex with GMP · 5GP A302 · binds VAL92, TYR93, ILE94, PHE106, GLY132, ASN133, TYR134, ILE178 and 4 more
  • 6O6B · Rotavirus A-VP3 (RVA-VP3) · 5GP A901 · binds HIS574, ARG577, HIS612, TYR648, HIS650
  • 6WCT · Crystal structure of a guanylate kinase from Stenotrophomonas maltophilia K279a bound to… · 5GP A301 · binds ALA21, SER23, LYS27, SER46, ARG50, ARG53, TYR62, GLU81 and 11 more
  • 6YK9 · [Fe]-hydrogenase from Methanolacinia paynteri with bound guanylylpyridinol at 1.7-A… · 5GP B401 · binds LEU9, GLY10, ALA11, GLY12, SER65, ASP66, PRO67, SER68 and 7 more
  • 7BF4 · Crystal structure of SARS-CoV-2 macrodomain in complex with GMP · 5GP A201 · binds ALA38, ASN40, LYS44, HIS45, GLY46, GLY47, GLY48, VAL49 and 2 more
  • 7U5F · Crystal structure of guanylate kinase from Pseudomonas aeruginosa PAO1 in complex with GMP · 5GP A300 · binds SER12, GLY13, ALA14, GLY15, LYS16, SER35, ARG39, ARG42 and 11 more

Residues it binds most

GLY 132, HIS 71, ASP 111, THR 107, ARG 106, SER 93, GLU 85, TYR 90, ALA 80, LYS 99 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol
  • MN · Manganese (II) ion
  • SO4 · Sulfate ion
  • GMP · Guanosine
  • K · Potassium ion
  • NA · Sodium ion
  • CL · Chloride ion
  • PO4 · Phosphate ion
  • GTP · Guanosine-5'-triphosphate

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