MolNFT v1 · #10373 · protein

Crystal structure of eukaryotic initiation factor 4E complexed with 7- methyl gpppa

1IPB · Eukaryotic translation initiation factor 4E: “Crystal structure of eukaryotic initiation factor 4E complexed with 7- methyl gpppa”. X-ray diffraction, 1 ligand (GTA), 1 pocket (best druggability 0.46). MolNFT v1 #10373 on GenesisL1…

PDB: 1IPB
Type: protein
Length: 191 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E
UniProt: P06730
Ligands: GTA
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E	protein	191	31% helix, 27% strand	P06730

Ligands and binding sites

GTA · P1-7-methylguanosine-P3-adenosine-5',5'-triphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.46	0.77	25	empty

Compared structures

1IPB · Crystal structure of eukaryotic initiation factor 4E complexed with 7-methyl gpppa · the same entry in another collection · chain A against A, TM-score 1.00
P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06730
Elsewhere: RCSB PDB 1IPB · PDBe 1IPB · UniProt P06730

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