UniProt P02554
Tubulin beta chain (P02554)
Tubulin beta chain (UniProt P02554): 163 experimental structures on GenesisL1, 28 ligands bound, 458 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P02554
- Protein
- Tubulin beta chain
- Experimental structures
- 163
- Predicted models
- 0
- Ligands
- 28
- Pockets
- 458 · 38 records with a druggable one
Structures
163 records of P02554 in the MolNFT archive: 163 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FFX | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | B, D | — | — |
| 1FFX | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | B, D | — | — |
| 1IA0 | KIF1A head-microtubule complex structure in ATP-form | electron microscopy | B | — | — |
| 1IA0 | KIF1A head-microtubule complex structure in ATP-form | electron microscopy | B | — | — |
| 1SA0 | Tubulin-colchicine: stathmin-like domain complex | x-ray diffraction | B, D | — | — |
| 1SA0 | Tubulin-colchicine: stathmin-like domain complex | x-ray diffraction | B, D | — | — |
| 1SA1 | Tubulin-podophyllotoxin: stathmin-like domain complex | x-ray diffraction | B, D, E | — | — |
| 1SA1 | Tubulin-podophyllotoxin: stathmin-like domain complex | x-ray diffraction | B, D, E | — | — |
| 1TUB | Tubulin alpha-beta dimer, electron diffraction | electron crystallography | B | — | — |
| 1TUB | Tubulin alpha-beta dimer, electron diffraction | electron crystallography | B | — | — |
| 1TVK | The binding mode of epothilone A on a,b-tubulin by electron crystallography | electron crystallography | B | — | — |
| 1TVK | The binding mode of epothilone a on A,B-tubulin by electron crystallography | electron crystallography | B | — | — |
| 2HXF | KIF1A head-microtubule complex structure in amppnp-form | electron microscopy | B | — | — |
| 2HXF | KIF1A head-microtubule complex structure in amppnp-form | electron microscopy | B | — | — |
| 2HXH | KIF1A head-microtubule complex structure in adp-form | electron microscopy | B | — | — |
| 2HXH | KIF1A head-microtubule complex structure in ADP-form | electron microscopy | B | — | — |
| 2WBE | Kinesin-5-Tubulin Complex with AMPPNP | electron microscopy | B | — | — |
| 2WBE | Kinesin-5-tubulin complex with amppnp | electron microscopy | B | — | — |
| 3EDL | Kinesin13-Microtubule Ring complex | electron microscopy | B, G | — | — |
| 3EDL | KINESIN13-microtubule ring complex | electron microscopy | B, G | — | — |
| 3J6E | Energy minimized average structure of Microtubules stabilized by GmpCpp | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6E | Energy minimized average structure of microtubules stabilized by gmpcpp | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6F | Minimized average structure of GDP-bound dynamic microtubules | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6F | Minimized average structure of GDP-bound dynamic microtubules | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6G | Minimized average structure of microtubules stabilized by taxol | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6G | Minimized average structure of microtubules stabilized by taxol | electron microscopy | B, D, F, H, J, L, N, P, R | — | — |
| 3J6H | Nucleotide-free Kinesin motor domain complexed with GMPCPP-microtubule | electron microscopy | B | — | — |
| 3J6H | Nucleotide-free kinesin motor domain complexed with gmpcpp-microtubule | electron microscopy | B | — | — |
| 3J6P | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoEM map | electron microscopy | B | — | — |
| 3J6P | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoem MAP | electron microscopy | B | — | — |
| 3J7I | Structure of alpha- and beta- tubulin in GMPCPP-microtubules | electron microscopy | B | — | — |
| 3J7I | Structure of alpha- and beta- tubulin in gmpcpp-microtubules | electron microscopy | B | — | — |
| 3JAK | Cryo-EM structure of GTPgammaS-microtubule co-polymerized with EB3 (merged dataset with and without… | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAK | Cryo-EM structure of gtpgammas-microtubule co-polymerized with EB3 (merged dataset with and without… | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAL | Cryo-EM structure of GMPCPP-microtubule co-polymerized with EB3 | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAL | Cryo-EM structure of gmpcpp-microtubule co-polymerized with EB3 | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAR | Cryo-EM structure of GDP-microtubule co-polymerized with EB3 | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAR | Cryo-EM structure of GDP-microtubule co-polymerized with EB3 | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAS | Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAS | Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAT | Cryo-EM structure of GMPCPP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAT | Cryo-EM structure of gmpcpp-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | F, G, D, I, B, H | — | — |
| 3JAW | Atomic model of a microtubule seam based on a cryo-EM reconstruction of the EB3-bound microtubule… | electron microscopy | B, D | — | — |
| 3JAW | Atomic model of a microtubule seam based on a cryo-EM reconstruction of the EB3-bound microtubule… | electron microscopy | B, D | — | — |
| 4ZHQ | Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex | x-ray diffraction | B, D | GTP, MG, GDP, CA, 4Q5 | 12 (best 0.82) |
| 4ZHQ | Crystal structure of tubulin-stathmin-ttl-mmae complex | x-ray diffraction | B, D | — | — |
| 4ZI7 | Crystal structure of tubulin-stathmin-ttl-HTI286 complex | x-ray diffraction | B, D | GTP, MG, GDP, CA, 4SL | 13 (best 0.82) |
| 4ZI7 | Crystal structure of tubulin-stathmin-ttl-HTI286 complex | x-ray diffraction | B, D | — | — |
| 4ZOL | Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex | x-ray diffraction | B, D | GTP, MG, GDP, 55Q | 14 (best 0.84) |
| 4ZOL | Crystal structure of tubulin-stathmin-ttl-tubulysin M complex | x-ray diffraction | B, D | — | — |
| 5BMV | CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX | x-ray diffraction | B, D | GTP, MG, GDP, CA, VLB | 12 (best 0.81) |
| 5BMV | Crystal structure of tubulin-stathmin-ttl-vinblastine complex | x-ray diffraction | B, D | — | — |
| 5FNV | a new complex structure of tubulin with an alpha-beta unsaturated lactone | x-ray diffraction | B, D | GTP, MG, GDP, CA | — |
| 5FNV | A new complex structure of tubulin with an alpha-beta unsaturated lactone | x-ray diffraction | B, D | — | — |
| 5JQG | An apo tubulin-RB-TTL complex structure used for side-by-side comparison | x-ray diffraction | B, D | GTP, MG, GDP, CA | 12 (best 0.83) |
| 5JQG | An apo tubulin-rb-ttl complex structure used for side-by-side comparison | x-ray diffraction | B, D | — | — |
| 5KMG | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | electron microscopy | B | GTP, GDP, POU | — |
| 5KMG | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | electron microscopy | B | GTP, GDP, POU | — |
| 5MM4 | Ustilago maydis kinesin-5 motor domain in the AMPPNP state bound to microtubules | electron microscopy | B | GTP, TA1, GDP | — |
| 5MM4 | Ustilago maydis kinesin-5 motor domain in the amppnp state bound to microtubules | electron microscopy | B | GTP, TA1, GDP | — |
103 records more on the page itself.
Ligands
- GTP · Guanosine-5'-triphosphate · in 99 records
- GDP · Guanosine-5'-diphosphate · in 80 records
- MG · Magnesium ion · in 60 records
- G2P · Phosphomethylphosphonic acid guanylate ester · in 23 records
- TA1 · Taxol · in 22 records
- CA · Calcium ion · in 9 records
- POU · Peloruside A · in 5 records
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 4 records
- O9B · (2~{R})-1-methylpiperidine-2-carboxylic acid · in 3 records
- J6L · 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one · in 2 records
- JEL · N-[[3-(1,3-benzodioxol-5-yloxy)phenyl]methyl]-9H-pyrido[3,4-b]indol-3-amine · in 2 records
- O9K · [(1~{R},3~{R})-1-(4-methanoyl-1,3-thiazol-2-yl)-4-methyl-3-(methylamino)pentyl] ethanoate · in 2 records
- O9N · methyl (2~{S},4~{S})-2,4-bis(azanyl)-5-phenyl-pentanoate · in 2 records
- PO4 · Phosphate ion · in 2 records
- S40 · 3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide · in 2 records
- TAJ · taccalonolide AJ · in 2 records
- 4Q5 · N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 1 record
- 4SL · N,beta,beta-trimethyl-L-phenylalanyl-N-[(3S,4Z)-5-carboxy-2-methylhex-4-en-3-yl]-N,3-dimethyl-L-valinamide · in 1 record
- 55Q · (2R,4R)-4-{[(2-{(1R,3R)-1-(acetyloxy)-4-methyl-3-[methyl(N-{[(2S)-1-methylpiperidin-2-yl]carbonyl}-D-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid · in 1 record
- FUO · 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl) ethanamide · in 1 record
- IUK · 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide · in 1 record
- O9H · [(1~{R},3~{R})-1-acetyloxy-1-[4-methanoyl-5-(2-phenylmethoxyethyl)-2,3-dihydro-1,3-thiazol-2-yl]-4-methyl-pentan-3-yl]-methyl-azanium · in 1 record
- OH5 · (2~{S},4~{R})-4-azanyl-2-methyl-5-phenyl-pentanoic acid · in 1 record
- P6S · benzyl hydrogen carbonate · in 1 record
- VAL · Valine · in 1 record
- VLB · (2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine · in 1 record
- XQ4 · (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methylamino)propanoyl]amino}propanoate (non-preferred name) · in 1 record
- ZPN · (2Z,4E)-N-[(S)-[(1S,2E,5S,8E,10Z,17S)-3,11-dimethyl-19-methylidene-7,13-dioxo-6,21-dioxabicyclo[15.3.1]henicosa-2,8,10-trien-5-yl](hydroxy)methyl]hexa-2,4-dienamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.