VLB · (2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine

Binding sites

VLB in 5 structures; the first of them:

• 5BMV · CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX · VLB C507 · binds PRO175, LYS176, VAL177, SER178, ASP179, TYR210, PHE214, THR220 and 16 more
• 5J2T · Tubulin-vinblastine complex · VLB C503 · binds LEU248, PRO325, LYS326, VAL328, ASN329, ILE332, ALA333, PHE351 and 15 more
• 8CLE · Vinblastine bound to tubulin (T2R-TTL) complex · VLB C501 · binds LEU248, PRO325, VAL328, ASN329, ILE332, ALA333, PHE351, VAL353 and 13 more
• 8CLH · Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound… · VLB C501 · binds PRO175, LYS176, VAL177, SER178, ASP179, TYR210, PHE214, THR220 and 14 more
• 7Z7D · Tubulin-todalam-vinblastine-complex · VLB B505 · binds PRO175, LYS176, VAL177, TYR210, PHE214, THR220, THR221, PRO222 and 14 more

Residues it binds most

PRO 5, THR 5, VAL 5, ILE 5, LEU 5, LYS 5, TYR 5, PHE 5, ALA 5, ASN 5 (residue and the binding sites it lines).

Found with

• GDP · Guanosine-5'-diphosphate
• GTP · Guanosine-5'-triphosphate
• CA · Calcium ion
• MG · Magnesium ion
• ACP · Phosphomethylphosphonic acid adenylate ester
• MES · 2-(N-morpholino)-ethanesulfonic acid
• 4I2 · N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide
• BKF · (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate
• EP · Epothilone A
• LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide
• POU · Peloruside A
• GOL · Glycerol