BKF · (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate

Binding sites

BKF in 4 structures; the first of them:

• 7E4P · Crystal structure of tubulin in complex with Ansamitocin P3 · BKF D502 · binds GLY98, ASN99, ASN100, LYS103, THR178, VAL179, VAL180, PHE394 and 1 more
• 8CLD · Ansamitocin P3 bound to tubulin (T2R-TTL) complex · BKF D502 · binds GLY98, ASN99, ASN100, LYS103, THR178, VAL179, VAL180, PHE394 and 1 more
• 8CLH · Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound… · BKF D504 · binds ALA99, GLY100, ASN101, ASN102, LYS105, THR180, VAL181, VAL182 and 3 more
• 7E4P · Crystal structure of tubulin in complex with ansamitocin P3 · BKF D502 · binds GLY98, ASN99, ASN100, LYS103, THR178, VAL179, VAL180, PHE394 and 1 more

Residues it binds most

ASN 4, VAL 4, GLY 4, LYS 4, PHE 4, THR 4, TRP 4, ALA 1, TYR 1 (residue and the binding sites it lines).

Found with

• ACP · Phosphomethylphosphonic acid adenylate ester
• GDP · Guanosine-5'-diphosphate
• GTP · Guanosine-5'-triphosphate
• CA · Calcium ion
• MG · Magnesium ion
• GOL · Glycerol
• MES · 2-(N-morpholino)-ethanesulfonic acid
• EP · Epothilone A
• LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide
• POU · Peloruside A
• VLB · (2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine