LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide

Binding sites

LOC in 21 structures; the first of them:

• 4X1K · Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications · LOC B502 · binds ASN101, SER178, THR179, ALA180, VAL181, VAL238, CYS241, LEU242 and 16 more
• 5EYP · Tubulin-darpin complex · LOC B502 · binds ASN101, SER178, THR179, ALA180, VAL181, VAL238, CYS241, LEU242 and 16 more
• 5ITZ · Crystal structure of the SAC domain of CPAP in a complex with Tubulin and Darpin · LOC B502 · binds SER178, THR179, ALA180, VAL181, CYS241, LEU242, LEU248, ALA250 and 12 more
• 5MIO · KIF2C-darpin fusion protein bound to tubulin · LOC B502 · binds ASN101, SER178, THR179, ALA180, VAL181, VAL238, CYS241, LEU242 and 16 more
• 5NKN · Crystal structure of an Anticalin-colchicine complex · LOC A201 · binds GLY40, PHE41, TYR56, VAL66, PHE68, GLN69, LYS70, PHE71 and 10 more
• 5NM5 · Tubulin Darpin room-temperature structure in complex with Colchicine determined by serial… · LOC B502 · binds SER178, THR179, ALA180, VAL181, VAL238, CYS241, LEU242, LEU248 and 16 more
• 5XIW · Crystal structure of T2R-TTL-Colchicine complex · LOC B504 · binds ASN101, SER178, THR179, ALA180, VAL181, VAL236, CYS239, LEU240 and 17 more
• 6AJZ · Joint nentron and X-ray structure of BRD4 in complex with colchicin · LOC A200 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR97, CYS136 and 4 more
• 6IN1 · Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6 · LOC A200 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR139, ASN140 and 2 more
• 6JWE · structure of RET G-quadruplex in complex with colchicine · LOC A101 · binds DG9, DG13, DG14, DC15, DG19, DT20
• 8CLB · Colchicine bound to tubulin (T2R-TTL) complex · LOC B503 · binds SER178, THR179, ALA180, VAL181, VAL238, CYS241, LEU242, LEU248 and 15 more
• 8CLG · Epothilone A and Colchicine bound to tubulin (T2R-TTL) complex · LOC B504 · binds ASN101, SER178, THR179, ALA180, VAL181, CYS241, LEU242, LEU248 and 14 more
• 8CLH · Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound… · LOC B503 · binds ASN101, SER178, THR179, ALA180, VAL181, CYS241, LEU242, LEU248 and 15 more
• 5MIO · KIF2C-darpin fusion protein bound to tubulin · LOC B502 · binds SER178, THR179, ALA180, VAL181, CYS241, LEU242, LEU248, ALA250 and 12 more
• 5NKN · Crystal structure of an anticalin-colchicine complex · LOC A201 · binds GLY40, PHE41, VAL66, PHE68, GLN69, LYS70, PHE71, MET73 and 8 more
• 5NM5 · Tubulin darpin room-temperature structure in complex with colchicine determined by serial… · LOC B502 · binds SER178, THR179, ALA180, VAL181, CYS241, LEU242, LEU248, ALA250 and 11 more
• 5XIW · Crystal structure of T2R-ttl-colchicine complex · LOC B504 · binds SER178, THR179, ALA180, VAL181, VAL236, CYS239, LEU240, LEU246 and 13 more
• 6AJZ · Joint nentron and X-ray structure of BRD4 in complex with colchicin · LOC A200 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR139, ASN140 and 2 more
• 6IN1 · Crystal structure of the first bromodomain of BRD4 in complex with 18- crown-6 · LOC A200 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR139, ASN140 and 2 more
• 6JWE · Structure of ret G-quadruplex in complex with colchicine · LOC A101 · binds DG9, DG13, DG14, DC15, DG19, DT20
• 6XER · Tubulin-RB3_SLD in complex with colchicine · LOC B502 · binds SER178, THR179, ALA180, VAL181, CYS239, LEU240, LEU246, ALA248 and 12 more

Residues it binds most

ALA 18, LEU 24, VAL 24, ASN 22, THR 20, LYS 20, ILE 22, MET 20, ASP 20, CYS 19 (residue and the binding sites it lines).

Found with

• GDP · Guanosine-5'-diphosphate
• GTP · Guanosine-5'-triphosphate
• MG · Magnesium ion
• CA · Calcium ion
• NA · Sodium ion
• ACP · Phosphomethylphosphonic acid adenylate ester
• GOL · Glycerol
• ANP · Phosphoaminophosphonic acid-adenylate ester
• EP · Epothilone A
• O4B · 1,4,7,10,13,16-hexaoxacyclooctadecane
• SO4 · Sulfate ion
• MES · 2-(N-morpholino)-ethanesulfonic acid