UniProt O00629
Importin subunit alpha-3 (O00629)
Importin subunit alpha-3 (UniProt O00629): 31 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 92 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00629
- Protein
- Importin subunit alpha-3
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 92 · 7 records with a druggable one
Structures
32 records of O00629 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UAE | Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain | x-ray diffraction | A | SO4 | 5 (best 0.50) |
| 4UAE | Importin alpha 3 delta ibb in complex with influenza PB2 nuclear localization domain | x-ray diffraction | A | SO4 | 5 (best 0.50) |
| 5TBK | Crystal structure of human importin a3 bound to RCC1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | 14 (best 0.81) |
| 5TBK | Crystal structure of human importin A3 bound to RCC1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | 14 (best 0.81) |
| 5XZX | Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding… | x-ray diffraction | A | — | 1 (best 0.32) |
| 5XZX | Crystal structure of importin-ALPHA3 bound to the nuclear localization signal of ran-binding… | x-ray diffraction | A | — | 1 (best 0.32) |
| 6BVV | Nipah virus W protein C-terminus in complex with Importin alpha 3 | x-ray diffraction | A | — | 1 (best 0.29) |
| 6BVV | Nipah virus W protein C-terminus in complex with importin alpha 3 | x-ray diffraction | A | — | 1 (best 0.29) |
| 6BVZ | Importin alpha 3 in cargo free state | x-ray diffraction | A | — | — |
| 6BVZ | Importin alpha 3 in cargo free state | x-ray diffraction | A | — | — |
| 6BW9 | Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1 | x-ray diffraction | A | — | 3 (best 0.33) |
| 6BW9 | Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 1 | x-ray diffraction | A | — | 3 (best 0.33) |
| 6BWA | Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2 | x-ray diffraction | A | — | 1 (best 0.27) |
| 6BWA | Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 2 | x-ray diffraction | A | — | 1 (best 0.27) |
| 6BWB | Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3 | x-ray diffraction | A | — | 1 (best 0.36) |
| 6BWB | Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 3 | x-ray diffraction | A | — | 1 (best 0.36) |
| 6WX8 | SOX2 bound to Importin-alpha 3 | x-ray diffraction | A, C | SO4 | 11 (best 0.75) |
| 6WX8 | SOX2 bound to importin-alpha 3 | x-ray diffraction | A, C | SO4 | — |
| 7JJL | Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS | x-ray diffraction | A | — | 1 (best 0.38) |
| 7JJL | Crystal structure of importin alpha 3 in complex with human LSD1 nls | x-ray diffraction | A | — | — |
| 7LF4 | Structure of importin a3 bound to the p50- and p65-NLSs | x-ray diffraction | A, C | — | 7 (best 0.51) |
| 7LF4 | Structure of importin A3 bound to the P50- and P65-nlss | x-ray diffraction | A, C | — | — |
| 7LFC | Structure of importin a3 bound to p50 NLS | x-ray diffraction | A | — | — |
| 7LFC | Structure of importin A3 bound to P50 nls | x-ray diffraction | A | — | — |
| 7RFY | Importin alpha3 in complex with MERS ORF4B | x-ray diffraction | A | — | 1 (best 0.24) |
| 7RFY | Importin ALPHA3 in complex with MERS ORF4B | x-ray diffraction | A | — | — |
| 7RG5 | Importin alpha3 in complex with p50 NLS | x-ray diffraction | A | — | — |
| 7RG5 | Importin ALPHA3 in complex with P50 nls | x-ray diffraction | A | — | — |
| 8FUB | Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein NLS1 | x-ray diffraction | A | — | 2 (best 0.37) |
| 8FZM | Human importin alpha 3 in complex with Bimax2 peptide | x-ray diffraction | A, C | — | 10 (best 0.59) |
| 8HKW | Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal | x-ray diffraction | A, B | — | 4 (best 0.84) |
| O00629 | AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) | predicted | A | — | 4 (best 0.60) |
Ligands
- SO4 · Sulfate ion · in 4 records
Experiment against prediction
- 8FZM chain A against the predicted model O00629: TM-score 0.99, RMSD 0.61 Å
- 7RG5 chain A against the predicted model O00629: TM-score 0.99, RMSD 0.66 Å
- 7RG5 chain A against the predicted model O00629: TM-score 0.99, RMSD 0.66 Å
- 7LFC chain A against the predicted model O00629: TM-score 0.99, RMSD 0.65 Å
- 7LFC chain A against the predicted model O00629: TM-score 0.99, RMSD 0.65 Å
- 8HKW chain A against the predicted model O00629: TM-score 0.99, RMSD 0.67 Å
- 6WX8 chain C against the predicted model O00629: TM-score 0.99, RMSD 0.68 Å
- 6WX8 chain C against the predicted model O00629: TM-score 0.99, RMSD 0.68 Å
- 7RFY chain A against the predicted model O00629: TM-score 0.99, RMSD 0.68 Å
- 7RFY chain A against the predicted model O00629: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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