MolNFT v1 · #180923 · protein
Structure of importin A3 bound to the P50- and P65-nlss
7LF4 · Importin subunit alpha-3: “Structure of importin A3 bound to the P50- and P65-nlss”. X-ray diffraction, 7 pockets (best druggability 0.51). MolNFT v1 #180923 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LF4
- Type
- protein
- Length
- 881 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-3; Nuclear factor nf-kappa-B P105 subunit; Transcription factor P65
- UniProt
- O00629, P19838, Q04206
- Pockets
- 7 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Importin subunit alpha-3 | protein | 416 | 74% helix, 0% strand | O00629 |
| B, F | Nuclear factor nf-kappa-B P105 subunit | protein | 11 | 0% helix, 0% strand | P19838 |
| D | Transcription factor P65 | protein | 14 | 0% helix, 0% strand | Q04206 |
| E | Transcription factor P65 | protein | 13 | 0% helix, 0% strand | Q04206 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.51 | 0.85 | 15 | empty |
| 2 | 164 | 0.44 | 0.75 | 27 | empty |
| 3 | 142 | 0.43 | 0.75 | 23 | empty |
| 4 | 114 | 0.38 | 0.74 | 18 | empty |
| 5 | 87 | 0.37 | 0.76 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 875 Ų buried · 16 hydrogen bonds · protein-protein
- C–F · 836 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 714 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 615 Ų buried · 3 hydrogen bonds · protein-protein
- A–E · 589 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7LF4 · Structure of importin a3 bound to the p50- and p65-NLSs · the same entry in another collection · chain E against E, TM-score 1.00
- O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P19838 · AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P19838) · a predicted model of the same protein · chain B against A, TM-score 0.43
- Q04206 · AlphaFold monomer V2.0 prediction for transcription factor P65 (Q04206) · a predicted model of the same protein · chain E against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00629
- Every structure of UniProt P19838
- Every structure of UniProt Q04206
- Elsewhere: RCSB PDB 7LF4 · PDBe 7LF4 · UniProt O00629 · UniProt P19838 · UniProt Q04206
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