UniProt Q04206
Transcription factor p65 (Q04206)
Transcription factor p65 (UniProt Q04206): 120 experimental structures on GenesisL1, 65 ligands bound, 27 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q04206
- Protein
- Transcription factor p65
- Experimental structures
- 120
- Predicted models
- 0
- Ligands
- 65
- Pockets
- 27 · 25 records with a druggable one
Structures
120 records of Q04206 in the MolNFT archive: 120 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NFI | I-kappa-B-ALPHA/NF-kappa-B complex | x-ray diffraction | A, C | — | — |
| 1NFI | I-kappa-B-ALPHA/NF-kappa-B complex | x-ray diffraction | A, C | — | — |
| 2LSP | solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide | solution nmr | A | — | — |
| 2LSP | Solution structures of BRD4 second bromodomain with nf-kb-K310AC peptide | solution nmr | A | — | — |
| 2O61 | Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer | x-ray diffraction | A | — | — |
| 2O61 | Crystal structure of nfkb, IRF7, IRF3 bound to the interferon-B enhancer | x-ray diffraction | A | — | — |
| 3GUT | Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR | x-ray diffraction | A, C, E, G | — | — |
| 3GUT | Crystal structure of a higher-order complex of P50:RELA bound to the HIV-1 ltr | x-ray diffraction | A, C, E, G | — | — |
| 3QXY | Human SETD6 in complex with RelA Lys310 | x-ray diffraction | P, Q | — | — |
| 3QXY | Human SETD6 in complex with rela LYS310 | x-ray diffraction | P, Q | — | — |
| 3RC0 | Human SETD6 in complex with RelA Lys310 peptide | x-ray diffraction | P, Q | — | — |
| 3RC0 | Human SETD6 in complex with rela LYS310 peptide | x-ray diffraction | P, Q | — | — |
| 4KV1 | Crystal Structure of Brd4 Bromodomain 1 in Complex with Acetylated Rel Peptide | x-ray diffraction | C, D | — | — |
| 4KV1 | Crystal structure of BRD4 bromodomain 1 in complex with acetylated rel peptide | x-ray diffraction | C, D | — | — |
| 4KV4 | Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide | x-ray diffraction | B | — | — |
| 4KV4 | BRD4 bromodomain 2 in complex with acetylated rel peptide | x-ray diffraction | B | — | — |
| 5U4K | NMR structure of the complex between the kix domain of cbp and the transactivation domain 1 of P65 | solution nmr | B | — | — |
| 5URN | NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the… | solution nmr | B | — | 1 (best 0.55) |
| 5URN | NMR structure of the complex between the pH domain of the TFB1 subunit from tfiih and the… | solution nmr | B | — | — |
| 6QHL | 14-3-3 sigma with RELA/P65 binding site PS45 | x-ray diffraction | P | — | — |
| 7BI3 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-179 | x-ray diffraction | P | TQW | — |
| 7BIQ | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-180 | x-ray diffraction | P | TVB, CL | — |
| 7BIW | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-187 | x-ray diffraction | P | TW8, CA | 1 (best 0.63) |
| 7BIW | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-187 | x-ray diffraction | P | TW8, CA | — |
| 7BIY | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 | x-ray diffraction | P | TWE | 1 (best 0.54) |
| 7BIY | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-175 | x-ray diffraction | P | TWE | — |
| 7BJB | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-044 | x-ray diffraction | P | TZK | — |
| 7BJF | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-069 | x-ray diffraction | P | TZH | 1 (best 0.56) |
| 7BJF | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-069 | x-ray diffraction | P | TZH | — |
| 7BJL | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-142 | x-ray diffraction | P | TWQ | 1 (best 0.54) |
| 7BJL | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-142 | x-ray diffraction | P | TWQ | — |
| 7BJW | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-154 | x-ray diffraction | P | TZW | — |
| 7BKH | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-153 | x-ray diffraction | P | U1B | — |
| 7LET | Structure of importin a2 bound to the p50- and p65-NLSs | x-ray diffraction | C | — | 1 (best 0.32) |
| 7LET | Structure of importin A2 bound to the P50- and P65-nlss | x-ray diffraction | C | — | — |
| 7LEU | Structure of importin a2 bound to p65-NLS | x-ray diffraction | B, C | — | — |
| 7LEU | Structure of importin A2 bound to P65-nls | x-ray diffraction | B, C | — | — |
| 7LF4 | Structure of importin A3 bound to the P50- and P65-nlss | x-ray diffraction | D, E | — | — |
| 7NJ9 | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-133 | x-ray diffraction | P | UGE | 1 (best 0.65) |
| 7NJ9 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-133 | x-ray diffraction | P | UGE | — |
| 7NJB | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-132 | x-ray diffraction | P | UG8 | — |
| 7NK3 | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-128 | x-ray diffraction | P | UGQ | 1 (best 0.55) |
| 7NK3 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-128 | x-ray diffraction | P | UGQ | — |
| 7NK5 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-124 | x-ray diffraction | P | UGN | — |
| 7NLA | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-119 | x-ray diffraction | P | UHT | 1 (best 0.56) |
| 7NLA | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-119 | x-ray diffraction | P | UHT | — |
| 7NLE | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-118 | x-ray diffraction | P | UHW | 1 (best 0.52) |
| 7NLE | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-118 | x-ray diffraction | P | UHW | — |
| 7NM1 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-126 | x-ray diffraction | P | UHN | — |
| 7NM3 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-135 | x-ray diffraction | P | UHQ | — |
| 7NM9 | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-110 | x-ray diffraction | P | — | — |
| 7NM9 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-110 | x-ray diffraction | P | — | — |
| 7NMH | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-070 | x-ray diffraction | P | UHZ | — |
| 7NMH | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-070 | x-ray diffraction | P | UHZ | — |
| 7NQP | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound LVD1009 | x-ray diffraction | P | — | — |
| 7NR7 | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-111 | x-ray diffraction | P | UON, UOT | 1 (best 0.55) |
| 7NR7 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-111 | x-ray diffraction | P | UON, UOT | — |
| 7NSV | 14-3-3 sigma with P65 (rela) binding site PS45 and covalently bound PC2046 | x-ray diffraction | P | UQN | — |
| 7NV4 | 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-188 | x-ray diffraction | P | UST | — |
| 7NVI | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-186 | x-ray diffraction | P | USW | 1 (best 0.64) |
60 records more on the page itself.
Ligands
- CA · Calcium ion · in 2 records
- TW8 · 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl) benzaldehyde · in 2 records
- TWE · 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile · in 2 records
- TWQ · 3-[(3~{S})-3-methoxypiperidin-1-yl]-4-nitro-benzaldehyde · in 2 records
- TZH · (5-methyl-2-nitro-phenyl) cyclobutanecarboxylate · in 2 records
- UGE · 4-(3,4-dihydro-2~{H}-quinolin-1-ylsulfonyl)benzaldehyde · in 2 records
- UGQ · 2-(4-methylphenyl)sulfonyl-3,4-dihydro-1~{H}-isoquinoline · in 2 records
- UHT · ~{N}-cyclohexyl-4-methanoyl-~{N}-methyl-benzenesulfonamide · in 2 records
- UHW · 4-(4-methylpiperazin-1-yl)sulfonylbenzaldehyde · in 2 records
- UHZ · (5-methanoyl-2-nitro-phenyl) methanesulfonate · in 2 records
- UON · 4-(2-chloranyl-5-methoxy-benzimidazol-1-yl)benzaldehyde · in 2 records
- UOT · 4-(2-chloranyl-6-methoxy-benzimidazol-1-yl)benzaldehyde · in 2 records
- USW · 4-[(7-chloranyl-2,3-dihydro-1,4-benzoxazin-4-yl) sulfonyl]benzaldehyde · in 2 records
- UT8 · 4-[(7-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl) sulfonyl]benzaldehyde · in 2 records
- UVE · 4-(2,3-dihydro-1,4-benzoxazin-4-ylsulfonyl)benzaldehyde · in 2 records
- UWH · 4-[4-(2-methoxyethyl)piperazin-1-yl]sulfonylbenzaldehyde · in 2 records
- UWK · 4-[(3~{R})-3-methoxypiperidin-1-yl]sulfonylbenzaldehyde · in 2 records
- UXN · 4-methanoyl-N-methyl-N-(oxan-4-yl)benzenesulfonamide · in 2 records
- V1E · ~{N},~{N},4-trimethylbenzenesulfonamide · in 2 records
- V1K · 2-chloranyl-6-methoxy-1-(4-methylphenyl)sulfonyl-benzimidazole · in 2 records
- V2E · 3-morpholin-4-yl-4-nitro-benzaldehyde · in 2 records
- V2K · 4-(5-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde · in 2 records
- V2N · 4-(6-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde · in 2 records
- V2T · 4-methanoyl-~{N}-(1-methylpyrazol-3-yl)benzamide · in 2 records
- V2W · 4-methanoyl-~{N}-[(4-methoxyphenyl)methyl]benzamide · in 2 records
- V32 · 4-morpholin-4-ylcarbonylbenzaldehyde · in 2 records
- V3B · 4-(4-methanoylphenyl)carbonyl-~{N},~{N}-dimethyl-piperazine-1-carboxamide · in 2 records
- V3K · 4-methanoyl-~{N}-[(1-methylpyrazol-4-yl) methyl]benzamide · in 2 records
- V3Z · (5-methanoyl-2-nitro-phenyl) propane-2-sulfonate · in 2 records
- V42 · (5-methanoyl-2-nitro-phenyl) 1-methylpyrazole-4-sulfonate · in 2 records
Experiment against prediction
- 2O61 chain A against the predicted model Q14653: TM-score 0.23, RMSD 7.18 Å
- 2O61 chain A against the predicted model Q14653: TM-score 0.23, RMSD 7.18 Å
Elsewhere
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