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Ligand · TWE

TWE · 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile

TWE, 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile (C14 H14 N2 O2, 242.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
TWE
Formula
C14 H14 N2 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

TWE in 2 structures; the first of them:

  • 7BIY · 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 · TWE A302 · binds LYS122, PRO167, ILE168, GLY171, LEU218, ILE219, ILE46, PRO47 and 1 more
  • 7BIY · 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-175 · TWE A302 · binds LYS122, PRO167, ILE168, GLY171, LEU218, ILE219, ILE46, PRO47 and 1 more

Residues it binds most

ILE 2, GLY 2, PRO 2, LEU 2, LYS 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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