MolNFT v1 · #186498 · protein

Importin ALPHA3 in complex with MERS ORF4B

7RFY · Importin subunit alpha-3: “Importin ALPHA3 in complex with MERS ORF4B”. X-ray diffraction, 1 pocket (best druggability 0.24). MolNFT v1 #186498 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RFY
Type: protein
Length: 404 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-3; ORF4B
UniProt: O00629, T2BB21
Pockets: 1 · best druggability 0.24

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-3	protein	389	76% helix, 0% strand	O00629
B	ORF4B	protein	15	0% helix, 0% strand	T2BB21

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.24	0.72	11	empty

Interfaces

1 interface between chains.

A–B · 1133 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

7RFY · Importin alpha3 in complex with MERS ORF4B · the same entry in another collection · chain B against B, TM-score 1.00
O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00629
Every structure of UniProt T2BB21
Elsewhere: RCSB PDB 7RFY · PDBe 7RFY · UniProt O00629 · UniProt T2BB21

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