MolNFT v1 · #144523 · protein
Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 1
6BW9 · Importin subunit alpha-3: “Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 1”. X-ray diffraction, 3 pockets (best druggability 0.33). MolNFT v1 #144523 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6BW9
- Type
- protein
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-3; Protein W
- UniProt
- O00629, P0C1C6
- Pockets
- 3 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-3 | protein | 416 | 74% helix, 0% strand | O00629 |
| B | Protein W | protein | 24 | 0% helix, 0% strand | P0C1C6 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.33 | 0.77 | 10 | empty |
| 2 | 64 | 0.30 | 0.74 | 15 | empty |
| 3 | 58 | 0.29 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1651 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 6BW9 · Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1 · the same entry in another collection · chain A against A, TM-score 1.00
- O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00629
- Every structure of UniProt P0C1C6
- Elsewhere: RCSB PDB 6BW9 · PDBe 6BW9 · UniProt O00629 · UniProt P0C1C6
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