MolNFT v1 · #140098 · protein
Crystal structure of importin-ALPHA3 bound to the nuclear localization signal of ran-binding protein 3
5XZX · Importin subunit alpha-3: “Crystal structure of importin-ALPHA3 bound to the nuclear localization signal of ran-binding protein 3”. X-ray diffraction, 1 pocket (best druggability 0.32). MolNFT v1 #140098 on GenesisL1: 3D structure…
- PDB
- 5XZX
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-3; Ran-binding protein 3
- UniProt
- O00629, Q9H6Z4
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-3 | protein | 414 | 71% helix, 0% strand | O00629 |
| B | Ran-binding protein 3 | protein | 14 | 0% helix, 0% strand | Q9H6Z4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.32 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 961 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5XZX · Crystal structure of importin-alpha3 bound to the nuclear localization signal of… · the same entry in another collection · chain A against A, TM-score 1.00
- O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9H6Z4 · AlphaFold monomer V2.0 prediction for ran-binding protein 3 (Q9H6Z4) · a predicted model of the same protein · chain B against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00629
- Every structure of UniProt Q9H6Z4
- Elsewhere: RCSB PDB 5XZX · PDBe 5XZX · UniProt O00629 · UniProt Q9H6Z4
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