MolNFT v1 · #144524 · protein

Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 2

6BWA · Importin subunit alpha-3: “Hendra virus W protein C-terminus in complex with importin alpha 3 crystal form 2”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #144524 on GenesisL1: 3D structure, binding sites and…

PDB: 6BWA
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-3; Protein W
UniProt: O00629, P0C1C6
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-3	protein	416	75% helix, 0% strand	O00629
B	Protein W	protein	26	0% helix, 0% strand	P0C1C6

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.27	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 1672 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

6BWA · Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2 · the same entry in another collection · chain B against B, TM-score 1.00
O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00629
Every structure of UniProt P0C1C6
Elsewhere: RCSB PDB 6BWA · PDBe 6BWA · UniProt O00629 · UniProt P0C1C6

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