UniProt A4TVL0
Cereblon isoform 4 (A4TVL0)
Cereblon isoform 4 (UniProt A4TVL0): 87 experimental structures on GenesisL1, 47 ligands bound, 139 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A4TVL0
- Protein
- Cereblon isoform 4
- Experimental structures
- 87
- Predicted models
- 0
- Ligands
- 47
- Pockets
- 139 · 28 records with a druggable one
Structures
87 records of A4TVL0 in the MolNFT archive: 87 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4V2Y | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide | x-ray diffraction | A, B, C | — | — |
| 4V2Y | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide | x-ray diffraction | A, B, C | — | — |
| 4V2Z | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pomalidomide | x-ray diffraction | A, B, C | — | — |
| 4V2Z | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide | x-ray diffraction | A, B, C | — | — |
| 4V30 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Lenalidomide | x-ray diffraction | A, B, C | — | — |
| 4V30 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide | x-ray diffraction | A, B, C | — | — |
| 4V31 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Deoxyuridine | x-ray diffraction | A, B, C | — | — |
| 4V31 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with deoxyuridine | x-ray diffraction | A, B, C | — | — |
| 4V32 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Y101F mutant | x-ray diffraction | A, B, C | — | — |
| 4V32 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, Y101F mutant | x-ray diffraction | A, B, C | — | — |
| 5AMH | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, trigonal… | x-ray diffraction | A | — | — |
| 5AMH | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal… | x-ray diffraction | A | — | — |
| 5AMI | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Wash I… | x-ray diffraction | A, B, C | — | — |
| 5AMI | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, wash I… | x-ray diffraction | A, B, C | — | — |
| 5AMJ | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Wash II… | x-ray diffraction | A, B, C | — | — |
| 5AMJ | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, wash II… | x-ray diffraction | A, B, C | — | — |
| 5AMK | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in multiple conformations, hexagonal… | x-ray diffraction | A, B, C, D | — | — |
| 5AMK | Cereblon isoform 4 from magnetospirillum gryphiswaldense in multiple conformations, hexagonal… | x-ray diffraction | A, B, C, D | — | — |
| 5OH1 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Aminoglutethimide | x-ray diffraction | A, B, C | ZN, EF2, 9UQ | — |
| 5OH1 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with aminoglutethimide | x-ray diffraction | A, B, C | ZN, EF2, 9UQ | — |
| 5OH2 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pyrrolidin-2-one… | x-ray diffraction | A, B, C | ZN, BAQ | 4 (best 0.50) |
| 5OH2 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pyrrolidin-2-one… | x-ray diffraction | A, B, C | ZN, BAQ | — |
| 5OH3 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Ethosuximide | x-ray diffraction | A, B, C | ZN, 9V2 | — |
| 5OH3 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with ethosuximide | x-ray diffraction | A, B, C | ZN, 9V2 | — |
| 5OH4 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidine-2,6-dione… | x-ray diffraction | A, B, C | ZN, 9UZ | 4 (best 0.57) |
| 5OH4 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with piperidine-2,6-dione… | x-ray diffraction | A, B, C | ZN, 9UZ | — |
| 5OH7 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Imidazolidine-2,4-dione… | x-ray diffraction | A, B, C | ZN, HYN | 3 (best 0.42) |
| 5OH7 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with imidazolidine-2,4-dione… | x-ray diffraction | A, B, C | ZN, HYN | — |
| 5OH8 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Rolipram | x-ray diffraction | A, B, C | ZN, ROL | 5 (best 0.47) |
| 5OH8 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with rolipram | x-ray diffraction | A, B, C | ZN, ROL | — |
| 5OH9 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thiazolidine-2,4-dione | x-ray diffraction | A, B, C | ZN, 9UT | — |
| 5OH9 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thiazolidine-2,4-dione | x-ray diffraction | A, B, C | ZN, 9UT | — |
| 5OHA | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with 2-Thiohydantoin | x-ray diffraction | A, B, C | ZN, 9UW | 4 (best 0.53) |
| 5OHA | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with 2-thiohydantoin | x-ray diffraction | A, B, C | ZN, 9UW | — |
| 5OHB | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidin-2-one… | x-ray diffraction | A, B, C | ZN, V1L | — |
| 5OHB | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with piperidin-2-one… | x-ray diffraction | A, B, C | ZN, V1L | — |
| 6R0Q | Mutant cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with thalidomide… | x-ray diffraction | A, B, C, D | ZN, JNW | 8 (best 0.63) |
| 6R0Q | Mutant cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide… | x-ray diffraction | A, B, C, D | ZN | — |
| 6R0S | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 4a and hydrolysis… | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOE, CL, JOH | 4 (best 0.52) |
| 6R0S | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 4A and hydrolysis… | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOE, CL, JOH | — |
| 6R0U | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 5a and hydrolysis… | x-ray diffraction | A, B, C | ZN, EF2, PO4, CL, JO8, JO5 | 3 (best 0.57) |
| 6R0U | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 5A and hydrolysis… | x-ray diffraction | A, B, C | ZN, EF2, PO4, CL, JO8, JO5 | — |
| 6R0V | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with hydrolysis product of… | x-ray diffraction | A, B, C | ZN, JO2, PO4, CL | 4 (best 0.44) |
| 6R0V | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with hydrolysis product of… | x-ray diffraction | A, B, C | ZN, JO2, PO4, CL | — |
| 6R11 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 5b | x-ray diffraction | A, B, C | ZN, JOB, PO4, CL | 4 (best 0.52) |
| 6R11 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 5B | x-ray diffraction | A, B, C | ZN, JOB, PO4, CL | — |
| 6R12 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7b | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOT, CL | 4 (best 0.60) |
| 6R12 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 7B | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOT, CL | — |
| 6R13 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7f | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOK, CL | 3 (best 0.63) |
| 6R13 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 7F | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOK, CL | — |
| 6R18 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 11a | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOQ, CL | 4 (best 0.60) |
| 6R18 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 11A | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOQ, CL | — |
| 6R19 | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 20a | x-ray diffraction | A, B, C | ZN, EF2, PO4, JON | 5 (best 0.51) |
| 6R19 | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 20A | x-ray diffraction | A, B, C | ZN, EF2, PO4, JON | — |
| 6R1A | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 20b | x-ray diffraction | A, B, C | ZN, EF2, PO4, JP8 | 4 (best 0.60) |
| 6R1A | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 20B | x-ray diffraction | A, B, C | ZN, EF2, PO4, JP8 | — |
| 6R1C | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 12a | x-ray diffraction | A, B, C | ASP, ZN, EF2, PO4, JOW, CL | 5 (best 0.54) |
| 6R1C | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 12A | x-ray diffraction | A, B, C | ZN, EF2, PO4, JOW, CL | — |
| 6R1D | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7d… | x-ray diffraction | A, B | ZN, JP5 | 1 (best 0.48) |
| 6R1D | Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 7D… | x-ray diffraction | A, B | ZN | — |
27 records more on the page itself.
Ligands
- ZN · Zinc ion · in 69 records
- PO4 · Phosphate ion · in 34 records
- EF2 · S-Thalidomide · in 24 records
- CL · Chloride ion · in 16 records
- 7SE · (3S)-3-(benzotriazol-2-yl)piperidine-2,6-dione · in 2 records
- 835 · (3S)-3-(5-azanyl-2-methyl-4-oxidanylidene-quinazolin-3-yl)piperidine-2,6-dione · in 2 records
- 9FT · (3R)-3-(4-methoxyphenyl)piperidine-2,6-dione · in 2 records
- 9UQ · (3~{R})-3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione · in 2 records
- 9UT · 1,3-thiazole-2,4-dione · in 2 records
- 9UW · 2-sulfanylideneimidazol-4-one · in 2 records
- 9UZ · piperidine-2,6-dione · in 2 records
- 9V2 · (3~{S})-3-ethyl-3-methyl-pyrrolidine-2,5-dione · in 2 records
- BAQ · pyrrolidin-2-one · in 2 records
- HYN · imidazolidine-2,4-dione · in 2 records
- JO2 · 2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]-4-nitro-benzoic acid · in 2 records
- JO5 · 4-azanyl-2-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]isoindole-1,3-dione · in 2 records
- JO8 · 3-azanyl-2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]benzoic acid · in 2 records
- JOB · 5-azanyl-2-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]isoindole-1,3-dione · in 2 records
- JOE · 2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]-6-nitro-benzoic acid · in 2 records
- JOH · 2-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-4-nitro-isoindole-1,3-dione · in 2 records
- JOK · ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-3-phenyl-propanamide · in 2 records
- JON · [(2~{S})-pyrrolidin-2-yl]methyl ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamate · in 2 records
- JOQ · [4-(aminomethyl)phenyl]methyl ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamate · in 2 records
- JOT · ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-2-phenyl-ethanamide · in 2 records
- JOW · 4-[[4-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyloxymethyl]phenyl]methylamino]-4-oxidanylidene-butanoic acid · in 2 records
- JP8 · [(2~{R})-pyrrolidin-2-yl]methyl ~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]carbamate · in 2 records
- JPB · ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-2, 4,6-tris(chloranyl)benzamide · in 2 records
- JPQ · ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-3-methyl-but-2-enamide · in 2 records
- JPW · (4-azanylcyclohexyl)methyl ~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]carbamate · in 2 records
- ROL · Rolipram · in 2 records
Elsewhere
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