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Ligand · LVY

LVY · S-Lenalidomide

LVY, S-Lenalidomide (C13 H13 N3 O3, 259.3 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
LVY
Formula
C13 H13 N3 O3
Class
ligand
Structures
9
PDB entries
5

Binding sites

LVY in 9 structures; the first of them:

  • 4CI2 · Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide · LVY B1429 · binds VAL352, ASN353, PRO354, HIS355, HIS359, GLU379, HIS380, SER381 and 4 more
  • 4TZ4 · Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide · LVY C502 · binds VAL350, ASN351, PRO352, HIS353, HIS357, HIS378, SER379, TRP380 and 3 more
  • 4V30 · Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Lenalidomide · LVY A151 · binds PHE49, ASN50, PRO51, PHE56, PHE77, SER78, TRP79, TRP85 and 2 more
  • 5FQD · Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase · LVY B1438 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 9 more
  • 8RQA · Crystal structure of CRBN-midi in complex with Lenalidomide · LVY A501 · binds VAL350, ASN351, PRO352, HIS353, HIS357, GLU377, HIS378, SER379 and 4 more
  • 4CI2 · Structure of the DDB1-crbn E3 ubiquitin ligase bound to lenalidomide · LVY B1429 · binds VAL352, ASN353, PRO354, HIS355, HIS359, GLU379, HIS380, SER381 and 4 more
  • 4TZ4 · Crystal structure of human cereblon in complex with DDB1 and lenalidomide · LVY C502 · binds VAL350, ASN351, PRO352, HIS353, HIS357, HIS378, SER379, TRP380 and 3 more
  • 4V30 · Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with lenalidomide · LVY A151 · binds PHE49, ASN50, PRO51, PHE56, PHE77, SER78, TRP79, TRP85 and 2 more
  • 5FQD · Structural basis of lenalidomide induced CK1A degradation by the CRL4CRBN ubiquitin ligase · LVY B1438 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 9 more

Residues it binds most

TRP 15, ASN 15, HIS 9, PHE 15, PRO 15, SER 15, GLU 9, VAL 9, ILE 4, TYR 6 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion

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