Ligand · Y70
Y70 · S-Pomalidomide
Y70, S-Pomalidomide (C13 H11 N3 O4, 273.2 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.
- Component
- Y70
- Formula
- C13 H11 N3 O4
- Class
- ligand
- Structures
- 11
- PDB entries
- 7
Binding sites
Y70 in 11 structures; the first of them:
- 6H0F · Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) · Y70 B502 · binds ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380, TRP386 and 8 more
- 6H0G · Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4) · Y70 B502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 7 more
- 6UML · Structural Basis for Thalidomide Teratogenicity Revealed by the… · Y70 C502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 8 more
- 8D81 · Cereblon~DDB1 bound to Pomalidomide · Y70 B502 · binds VAL350, ASN351, PRO352, HIS353, HIS378, SER379, TRP380, PHE381 and 4 more
- 8OIZ · Crystal structure of human CRBN-DDB1 in complex with Pomalidomide · Y70 B502 · binds VAL350, ASN351, PRO352, HIS353, HIS357, GLU377, HIS378, SER379 and 4 more
- 8TNP · Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 · Y70 B502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 9 more
- 8U17 · The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide · Y70 A502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 8 more
- 6H0F · Structure of DDB1-crbn-pomalidomide complex bound to IKZF1(ZF2) · Y70 B502 · binds ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380, TRP386 and 8 more
- 6H0G · Structure of the DDB1-crbn-pomalidomide complex bound to ZNF692(ZF4) · Y70 B502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 7 more
- 6UML · Structural basis for thalidomide teratogenicity revealed by the… · Y70 C502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 8 more
- 8D81 · CEREBLON~DDB1 bound to pomalidomide · Y70 B502 · binds VAL350, PRO352, HIS353, HIS378, SER379, TRP380, TRP386, HIS397 and 2 more
Residues it binds most
TRP 20, HIS 20, CYS 17, ASN 19, PHE 20, PRO 20, SER 20, GLN 12, GLU 18, VAL 10 (residue and the binding sites it lines).
Found with
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