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Ligand · JO2

JO2 · 2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]-4-nitro-benzoic acid

JO2, 2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]-4-nitro-benzoic acid (C12 H9 N3 O7, 307.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
JO2
Formula
C12 H9 N3 O7
Class
ligand
Structures
2
PDB entries
1

Binding sites

JO2 in 2 structures; the first of them:

  • 6R0V · Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with hydrolysis… · JO2 A202 · binds ASN50, PRO51, MET54, GLU76, PHE77, SER78, TRP79, TRP85 and 4 more
  • 6R0V · Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with hydrolysis… · JO2 A202 · binds ASN50, PRO51, PHE77, SER78, TRP79, TRP85, ILE87, HIS96 and 2 more

Residues it binds most

TRP 6, PHE 6, ASN 6, HIS 6, ILE 6, PRO 6, SER 6, TYR 6, GLU 2, MET 1 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • CL · Chloride ion
  • PO4 · Phosphate ion

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