MolNFT v2 · #179197 · protein

Crystal structure of tubulin in complex with Maytansinol

7E4Z: “Crystal structure of tubulin in complex with Maytansinol”. X-ray diffraction at 2.69, 7 ligands (GTP, GDP, BKL). MolNFT v2 #179197 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7E4Z
Type: protein
Length: 2,197 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.69
Source: Bos taurus; Gallus gallus; Rattus norvegicus
UniProt: P81947, Q6B856, P63043, E1BQ43
Ligands: GTP, GDP, BKL, ACP, MG, CA, CL

Structure

x-ray diffraction · resolution 2.69 · 5 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	—	protein	440	—	P81947
B	—	protein	425	—	Q6B856
D	—	protein	421	—	Q6B856
E	—	protein	123	—	P63043
F	—	protein	348	—	E1BQ43

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · 3 copies · chains A, B, C, D
GDP · Guanosine-5'-diphosphate · ligand · chains B
BKL · (1R,2S,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione · ligand · chains D
ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
MG · Magnesium ion · metal · 5 copies · chains A, B, C, D
CA · Calcium ion · metal · 4 copies · chains A, B, C, E
CL · Chloride ion · ion · chains A
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 3 copies · chains A, B, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7E4Z · Crystal structure of tubulin in complex with maytansinol · the same entry in another collection · chain C against C, TM-score 1.00
P81947 · AlphaFold monomer V2.0 prediction for tubulin alpha-1B chain (P81947) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P81947
Every structure of UniProt Q6B856
Every structure of UniProt P63043
Every structure of UniProt E1BQ43
Elsewhere: RCSB PDB 7E4Z · PDBe 7E4Z · UniProt P81947 · UniProt Q6B856 · UniProt P63043 · UniProt E1BQ43

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