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Ligand · BKL

BKL · (1R,2S,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione

BKL, (1R,2S,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione (C28 H37 Cl N2 O8, 565.1 g/mol), in…

Component
BKL
Formula
C28 H37 Cl N2 O8
Class
ligand
Structures
2
PDB entries
1

Binding sites

BKL in 2 structures; the first of them:

  • 7E4Z · Crystal structure of tubulin in complex with Maytansinol · BKL D603 · binds GLY100, ASN101, ASN102, LYS105, ASP179, THR180, VAL181, VAL182 and 2 more
  • 7E4Z · Crystal structure of tubulin in complex with maytansinol · BKL D603 · binds GLY100, ASN101, ASN102, LYS105, ASP179, THR180, VAL181, VAL182 and 2 more

Residues it binds most

ASN 2, VAL 2, ASP 2, GLY 2, LYS 2, PHE 2, THR 2, TRP 2 (residue and the binding sites it lines).

Found with

  • ACP · Phosphomethylphosphonic acid adenylate ester
  • GDP · Guanosine-5'-diphosphate
  • GTP · Guanosine-5'-triphosphate
  • CA · Calcium ion
  • MG · Magnesium ion
  • CL · Chloride ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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