UniProt P81947
Tubulin alpha-1B chain (P81947)
Tubulin alpha-1B chain (UniProt P81947): 270 experimental structures and 1 predicted model on GenesisL1, 113 ligands bound, 313 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P81947
- Protein
- Tubulin alpha-1B chain
- Experimental structures
- 270
- Predicted models
- 1
- Ligands
- 113
- Pockets
- 313 · 30 records with a druggable one
Structures
271 records of P81947 in the MolNFT archive: 270 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J2U | Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule | electron microscopy | A, C | — | — |
| 3J2U | Kinesin-13 KLP10A hd in complex with cs-tubulin and a microtubule | electron microscopy | A, C | — | — |
| 4I4T | Crystal structure of tubulin-RB3-TTL-Zampanolide complex | x-ray diffraction | A, C | — | — |
| 4I4T | Crystal structure of tubulin-RB3-ttl-zampanolide complex | x-ray diffraction | A, C | — | — |
| 4I50 | Crystal structure of tubulin-stathmin-TTL-Epothilone A complex | x-ray diffraction | A, C | — | — |
| 4I50 | Crystal structure of tubulin-stathmin-ttl-epothilone a complex | x-ray diffraction | A, C | — | — |
| 4I55 | Crystal structure of tubulin-stathmin-TTL complex | x-ray diffraction | A, C | — | — |
| 4I55 | Crystal structure of tubulin-stathmin-ttl complex | x-ray diffraction | A, C | — | — |
| 4IHJ | Crystal structure of tubulin-stathmin-TTL-ADP complex | x-ray diffraction | A, C | — | — |
| 4IHJ | Crystal structure of tubulin-stathmin-ttl-ADP complex | x-ray diffraction | A, C | — | — |
| 4IIJ | Crystal structure of tubulin-stathmin-TTL-apo complex | x-ray diffraction | A, C | — | — |
| 4IIJ | Crystal structure of tubulin-stathmin-ttl-apo complex | x-ray diffraction | A, C | — | — |
| 4O2A | Tubulin-BAL27862 complex | x-ray diffraction | A, C | — | — |
| 4O2A | Tubulin-BAL27862 complex | x-ray diffraction | A, C | — | — |
| 4O2B | Tubulin-Colchicine complex | x-ray diffraction | A, C | — | — |
| 4O2B | Tubulin-colchicine complex | x-ray diffraction | A, C | — | — |
| 4O4H | Tubulin-Laulimalide complex | x-ray diffraction | A, C | — | — |
| 4O4H | Tubulin-laulimalide complex | x-ray diffraction | A, C | — | — |
| 4O4I | Tubulin-Laulimalide-Epothilone A complex | x-ray diffraction | A, C | — | — |
| 4O4I | Tubulin-laulimalide-epothilone a complex | x-ray diffraction | A, C | — | — |
| 4O4J | Tubulin-Peloruside A complex | x-ray diffraction | A, C | — | — |
| 4O4J | Tubulin-peloruside a complex | x-ray diffraction | A, C | — | — |
| 4O4L | Tubulin-Peloruside A-Epothilone A complex | x-ray diffraction | A, C | — | — |
| 4O4L | Tubulin-peloruside a-epothilone a complex | x-ray diffraction | A, C | — | — |
| 4TUY | Tubulin-Rhizoxin complex | x-ray diffraction | A, C | — | — |
| 4TUY | Tubulin-rhizoxin complex | x-ray diffraction | A, C | — | — |
| 4TV8 | Tubulin-Maytansine complex | x-ray diffraction | A, C | — | — |
| 4TV8 | Tubulin-maytansine complex | x-ray diffraction | A, C | — | — |
| 4TV9 | Tubulin-PM060184 complex | x-ray diffraction | A, C | — | — |
| 4TV9 | Tubulin-PM060184 complex | x-ray diffraction | A, C | — | — |
| 4UXO | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXO | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXP | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXP | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXR | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXR | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXS | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXS | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXT | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXT | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXY | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UXY | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UY0 | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4UY0 | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | A | — | — |
| 4YJ2 | Crystal structure of tubulin bound to MI-181 | x-ray diffraction | A, C | — | — |
| 4YJ2 | Crystal structure of tubulin bound to mi-181 | x-ray diffraction | A, C | — | — |
| 4YJ3 | Crystal structure of tubulin bound to compound 2 | x-ray diffraction | A, C | — | — |
| 4YJ3 | Crystal structure of tubulin bound to compound 2 | x-ray diffraction | A, C | — | — |
| 5BMV | CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX | x-ray diffraction | A, C | GTP, MG, CA, VLB | 15 (best 0.81) |
| 5BMV | Crystal structure of tubulin-stathmin-ttl-vinblastine complex | x-ray diffraction | A, C | — | — |
| 5EIB | Crystal structure of CPAP PN2-3 C-terminal loop-helix in complex with DARPin-tubulin | x-ray diffraction | C | GTP, MG | 7 (best 0.80) |
| 5EIB | Crystal structure of cpap PN2-3 C-terminal loop-helix in complex with darpin-tubulin | x-ray diffraction | C | — | — |
| 5GON | Structures of a beta-lactam bridged analogue in complex with tubulin | x-ray diffraction | A, C | GTP, MG, CA, 6ZR | — |
| 5GON | Structures of a beta-lactam bridged analogue in complex with tubulin | x-ray diffraction | A, C | — | — |
| 5HNW | Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the AMPPNP state | electron microscopy | A | MG, GTP | — |
| 5HNW | Structural basis of backwards motion in kinesin-14: minus-end directed NKN664 in the amppnp state | electron microscopy | A | — | — |
| 5HNX | Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the… | electron microscopy | A | MG, GTP | — |
| 5HNX | Structural basis of backwards motion in kinesin-14: minus-end directed NKN664 in the… | electron microscopy | A | — | — |
| 5HNY | Structural basis of backwards motion in kinesin-14: plus-end directed nKn669 in the AMPPNP state | electron microscopy | A | GTP, MG | — |
| 5HNY | Structural basis of backwards motion in kinesin-14: plus-end directed NKN669 in the amppnp state | electron microscopy | A | — | — |
211 records more on the page itself.
Ligands
- GTP · Guanosine-5'-triphosphate · in 206 records
- MG · Magnesium ion · in 185 records
- CA · Calcium ion · in 170 records
- CL · Chloride ion · in 9 records
- GDP · Guanosine-5'-diphosphate · in 5 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 4 records
- IBL · Azo-Combretastatin A4 (cis) · in 4 records
- 4I2 · N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide · in 3 records
- 8WB · 2-methoxy-5-(2,3,4-trimethoxyphenyl)cyclohepta-2,4,6-trien-1-one · in 3 records
- LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · in 3 records
- VLB · (2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine · in 3 records
- VYT · Azo-Combretastatin A4 (trans) · in 3 records
- 47F · N-[4-(2-anilino-1,3-thiazol-4-yl)phenyl]acetamide · in 2 records
- 4B6 · N-{4-[2-(2-fluoroanilino)-1,3-thiazol-4-yl]phenyl}acetamide · in 2 records
- 6NL · (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(7-methoxy-2H-1,3-benzodioxol-5-yl)-2-methylprop-2-en-1-one · in 2 records
- 84F · (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4, 5-trimethoxyphenyl)azetidin-2-one · in 2 records
- 89O · (5S,5aR,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one · in 2 records
- 94U · N-[4-(diethylamino)phenyl]-4H-pyrrolo[2,3-D][1, 3]thiazole-5-carboxamide · in 2 records
- 97O · 6,7,8-trimethoxy-1-(4-methoxyphenyl)-4,5-dihydro-2~{H}-benzo[e]indazole · in 2 records
- AYV · 1-[2-methyl-1,3-bis(oxidanyl)propan-2-yl]-3-phenyl-urea · in 2 records
- D3L · (5-methoxy-1H-indol-2-yl)-phenyl-methanone · in 2 records
- DLK · 2-{1-[(2-Methoxyphenyl)amino]ethylidene}-5-phenyl-1,3-cyclohexanedione · in 2 records
- EZW · 5-(quinolin-5-yl)naphtho[2,3-b]pyrrolo[1,2-D][1, 4]oxazepin-4-yl acetate · in 2 records
- FB7 · 5-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-(trifluoromethyl)pyridin-2-amine · in 2 records
- OBQ · (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one · in 2 records
- PN6 · (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione · in 2 records
- S9S · ~{N}-[2-(4-fluorophenyl)ethyl]methanesulfonamide · in 2 records
- SD5 · 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine · in 2 records
- SO4 · Sulfate ion · in 2 records
- STV · ~{N}-(1,3-benzodioxol-5-ylmethyl)ethanesulfonamide · in 2 records
Experiment against prediction
- 6RFD chain A against the predicted model P81947: TM-score 0.99, RMSD 0.68 Å
- 6RFD chain a against the predicted model P81947: TM-score 0.99, RMSD 0.68 Å
- 5HNY chain A against the predicted model P81947: TM-score 0.98, RMSD 1.12 Å
- 5HNW chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 3J2U chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 5HNX chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 4UXO chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 4UXP chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 4UXR chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
- 4UXS chain A against the predicted model P81947: TM-score 0.98, RMSD 1.14 Å
Elsewhere
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