MolNFT v2 · #179189 · protein
Crystal structure of tubulin in complex with D-DM1-SMe
7E4R: “Crystal structure of tubulin in complex with D-DM1-SMe”. X-ray diffraction at 2.597, 6 ligands (GTP, GDP, HZ0). MolNFT v2 #179189 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E4R
- Type
- protein
- Length
- 2,180 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.597
- Source
- Bos taurus; Gallus gallus; Rattus norvegicus
- UniProt
- P81947, Q6B856, P63043, E1BQ43
- Ligands
- GTP, GDP, HZ0, ACP, MG, CA
Structure
x-ray diffraction · resolution 2.597 · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 437 | — | P81947 |
| B | — | protein | 427 | — | Q6B856 |
| C | — | protein | 440 | — | P81947 |
| D | — | protein | 421 | — | Q6B856 |
| E | — | protein | 121 | — | P63043 |
| F | — | protein | 334 | — | E1BQ43 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 3 copies · chains A, B, C, D
- GDP · Guanosine-5'-diphosphate · ligand · chains B
- HZ0 · (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7, 10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2, 3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl) propanoyl)-D-alaninate · ligand · chains D
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
- MG · Magnesium ion · metal · 4 copies · chains B, C, D
- CA · Calcium ion · metal · 2 copies · chains A, C
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81947
- Every structure of UniProt Q6B856
- Every structure of UniProt P63043
- Every structure of UniProt E1BQ43
- Elsewhere: RCSB PDB 7E4R · PDBe 7E4R · UniProt P81947 · UniProt Q6B856 · UniProt P63043 · UniProt E1BQ43
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