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Ligand · HZ0

HZ0 · (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7, 10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2, 3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl) propanoyl)-D-alaninate

HZ0, (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7, 10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2, 3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl) propanoyl)-D-alaninate (C36…

Component
HZ0
Formula
C36 H50 Cl N3 O10 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

HZ0 in 2 structures; the first of them:

  • 7E4R · Crystal structure of tubulin in complex with D-DM1-SMe · HZ0 D502 · binds ALA97, GLY98, ASN99, ASN100, LYS103, THR178, VAL179, VAL180 and 2 more
  • 7E4R · Crystal structure of tubulin in complex with D-DM1-sme · HZ0 D502 · binds ALA97, GLY98, ASN99, ASN100, LYS103, THR178, VAL179, VAL180 and 2 more

Residues it binds most

ASN 2, VAL 2, ALA 2, GLY 2, LYS 2, PHE 2, THR 2, TRP 2 (residue and the binding sites it lines).

Found with

  • ACP · Phosphomethylphosphonic acid adenylate ester
  • GDP · Guanosine-5'-diphosphate
  • GTP · Guanosine-5'-triphosphate
  • CA · Calcium ion
  • MG · Magnesium ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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