MolNFT v1 · #188045 · protein
Native human tsh bound to human thyrotropin receptor in complex with MINIGS399 (composite structure)
7T9I: “Native human tsh bound to human thyrotropin receptor in complex with MINIGS399 (composite structure)”. Electron microscopy, 1 ligand (NAG). MolNFT v1 #188045 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7T9I
- Type
- protein
- Length
- 1,532 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P01215, P01222, A0A0A0MTJ0, P63092, P62873, P59768
- Ligands
- NAG
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 86 | — | P01215 |
| B | — | protein | 109 | — | P01222 |
| N | — | protein | 126 | — | — |
| R | — | protein | 596 | — | A0A0A0MTJ0 |
| X | — | protein | 221 | — | P63092 |
| Y | — | protein | 338 | — | P62873 |
| Z | — | protein | 56 | — | P59768 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T9I · Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite… · the same entry in another collection · chain Z against Z, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain Y against A, TM-score 0.99
- P01215 · AlphaFold monomer V2.0 prediction for glycoprotein hormones alpha chain (P01215) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P01222 · AlphaFold monomer V2.0 prediction for thyrotropin subunit beta (P01222) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Z against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01215
- Every structure of UniProt P01222
- Every structure of UniProt A0A0A0MTJ0
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7T9I · PDBe 7T9I · UniProt P01215 · UniProt P01222 · UniProt A0A0A0MTJ0 · UniProt P63092 · UniProt P62873 · UniProt P59768
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.