MolNFT v1 · #480972 · protein
AlphaFold monomer V2.0 prediction for thyrotropin subunit beta (P01222)
P01222: “AlphaFold monomer V2.0 prediction for thyrotropin subunit beta (P01222)”. 1 pocket (best druggability 0.48). MolNFT v1 #480972 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P01222
- Type
- protein
- Length
- 138 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x94F0aFB48B380f0BD45716993326EDb0c4b82963
- Molecule
- Thyrotropin subunit beta
- UniProt
- P01222
- Pockets
- 1 · best druggability 0.48
Structure
1 distinct chain · 17% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyrotropin subunit beta | protein | 138 | 17% helix, 38% strand | P01222 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.48 | 0.73 | 26 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7UTZ · Human thyrotropin analog TR1402 bound to human thyrotropin receptor in complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.74
- 7UTZ · Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.74
- 7T9I · Native human tsh bound to human thyrotropin receptor in complex with MINIGS399 (composite… · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 7T9I · Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite… · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 7XW5 · Tshr-thyroid stimulating hormone-gs-ML109 complex · an experimental structure of the same protein · chain A against Y, TM-score 0.69
- 7XW5 · TSHR-thyroid stimulating hormone-Gs-ML109 complex · an experimental structure of the same protein · chain A against Y, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01222
- Elsewhere: UniProt P01222 · AlphaFold DB P01222
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