Research workbench
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
Analyse Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VDL
- Type
- protein
- Length
- 1,100 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63096, P62873, P59768, Q96LB1, O00230
- Ligands
- CLR
Structure
electron microscopy · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 215 | — | P63096 |
| B | — | protein | 339 | — | P62873 |
| C | — | protein | 55 | — | P59768 |
| S | — | protein | 230 | — | — |
| R | — | protein | 256 | — | Q96LB1 |
| L | — | protein | 5 | — | O00230 |
Ligands and binding sites
- CLR · Cholesterol · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7VDL · Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14 · the same entry in another collection · chain L against L, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q96LB1 · AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X2… · a predicted model of the same protein · chain R against A, TM-score 0.95
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.94
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
- O00230 · AlphaFold monomer V2.0 prediction for cortistatin (O00230) · a predicted model of the same protein · chain L against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt Q96LB1
- Every structure of UniProt O00230
- Elsewhere: RCSB PDB 7VDL · PDBe 7VDL · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt Q96LB1 · UniProt O00230
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