UniProt Q96LB1
Mas-related G-protein coupled receptor member X2 (Q96LB1)
Mas-related G-protein coupled receptor member X2 (UniProt Q96LB1): 26 experimental structures on GenesisL1, 3 ligands bound, 37 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q96LB1
- Protein
- Mas-related G-protein coupled receptor member X2
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 37 · 9 records with a druggable one
Structures
26 records of Q96LB1 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7S8L | Cryoem structure of gq-coupled MRGPRX2 with peptide agonist cortistatin-14 | electron microscopy | R | — | — |
| 7S8M | CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 | electron microscopy | R | — | 5 (best 0.72) |
| 7S8M | Cryoem structure of gi-coupled MRGPRX2 with peptide agonist cortistatin-14 | electron microscopy | R | — | — |
| 7S8N | CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | electron microscopy | R | 8IU | 7 (best 0.70) |
| 7S8N | Cryoem structure of gq-coupled MRGPRX2 with small molecule agonist (R)-zinc-3573 | electron microscopy | R | 8IU | — |
| 7S8O | CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | electron microscopy | R | 8IU | 4 (best 0.70) |
| 7S8O | Cryoem structure of gi-coupled MRGPRX2 with small molecule agonist (R)-zinc-3573 | electron microscopy | R | 8IU | — |
| 7VDH | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | electron microscopy | R | CLR, 6IB | 5 (best 0.74) |
| 7VDH | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, STATE2 | electron microscopy | R | CLR, 6IB | — |
| 7VDL | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14 | electron microscopy | R | CLR | 3 (best 0.72) |
| 7VDL | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14 | electron microscopy | R | CLR | — |
| 7VDM | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P | electron microscopy | R | CLR | 4 (best 0.76) |
| 7VDM | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P | electron microscopy | R | CLR | — |
| 7VUY | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with pamp-12. STATE1 | electron microscopy | R | CLR | — |
| 7VUZ | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | electron microscopy | R | CLR | 4 (best 0.72) |
| 7VUZ | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with pamp-12, STATE2 | electron microscopy | R | CLR | — |
| 7VV0 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local | electron microscopy | R | CLR | 2 (best 0.71) |
| 7VV0 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with pamp-12, local | electron microscopy | R | CLR | — |
| 7VV3 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14 | electron microscopy | R | CLR | — |
| 7VV3 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14 | electron microscopy | R | CLR | — |
| 7VV4 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local | electron microscopy | R | CLR | — |
| 7VV5 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | electron microscopy | R | CLR, 6IB | 3 (best 0.76) |
| 7VV5 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, STATE1 | electron microscopy | R | CLR, 6IB | — |
| 7VV6 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | electron microscopy | R | CLR, 6IB | — |
| 7VV6 | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | electron microscopy | R | CLR, 6IB | — |
| Q96LB1 | AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X2 (Q96LB1) | — | — | — |
Ligands
- CLR · Cholesterol · in 18 records
- 6IB · 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino) ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine · in 6 records
- 8IU · (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine · in 4 records
Experiment against prediction
- 7S8M chain R against the predicted model P0ABE7: TM-score 0.28, RMSD 4.24 Å
- 7S8M chain R against the predicted model P0ABE7: TM-score 0.28, RMSD 4.24 Å
- 7S8O chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.78 Å
- 7S8O chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.78 Å
Elsewhere
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