Research workbench

Human AMYLIN2 receptor in complex with gs and human calcitonin peptide

Analyse Human AMYLIN2 receptor in complex with gs and human calcitonin peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TYH
Type: protein
Length: 1,246 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
UniProt: P63092, P62873, P59768, O60895, P01258, P30988
Ligands: NH2
Pockets: 13 · best druggability 0.82

Structure

electron microscopy · 7 distinct chains · 35% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(S) subunit alpha isoforms short	protein	229	42% helix, 17% strand	P63092
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	338	7% helix, 41% strand	P62873
G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	54	48% helix, 0% strand	P59768
N	Nanobody 35	protein	127	0% helix, 40% strand	—
E	Receptor activity-modifying protein 2	protein	97	64% helix, 0% strand	O60895
P	Calcitonin	protein	32	44% helix, 0% strand	P01258
R	Calcitonin receptor	protein	369	59% helix, 4% strand	P30988

Ligands and binding sites

NH2 · Amino group · ion · chains P, R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	721	0.82	0.86	74	empty
2	1032	0.77	0.79	66	empty
3	920	0.75	0.78	95	empty
4	817	0.74	0.79	58	empty
5	588	0.72	0.80	53	empty

Interfaces

9 interfaces between chains.

B–G · 2093 Å² buried · 19 hydrogen bonds · protein-protein
P–R · 1888 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1538 Å² buried · 19 hydrogen bonds · protein-protein
A–R · 1239 Å² buried · 12 hydrogen bonds · protein-protein
A–N · 998 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

7TYH · Human Amylin2 Receptor in complex with Gs and human calcitonin peptide · the same entry in another collection · chain R against R, TM-score 1.00
P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.89
P30988 · AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) · a predicted model of the same protein · chain R against A, TM-score 0.87
O60895 · AlphaFold monomer V2.0 prediction for receptor activity-modifying protein 2 (O60895) · a predicted model of the same protein · chain E against A, TM-score 0.65
P01258 · AlphaFold monomer V2.0 prediction for calcitonin (P01258) · a predicted model of the same protein · chain P against A, TM-score 0.48

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63092
Every structure of UniProt P62873
Every structure of UniProt P59768
Every structure of UniProt O60895
Every structure of UniProt P01258
Every structure of UniProt P30988
Elsewhere: RCSB PDB 7TYH · PDBe 7TYH · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt O60895 · UniProt P01258 · UniProt P30988

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