UniProt P30988
Calcitonin receptor (P30988)
Calcitonin receptor (UniProt P30988): 32 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30988
- Protein
- Calcitonin receptor
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 90 · 14 records with a druggable one
Structures
33 records of P30988 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5II0 | Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon… | x-ray diffraction | A, B, C | URE | — |
| 5II0 | Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon… | x-ray diffraction | A, B, C | — | — |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs… | electron microscopy | R | — | 7 (best 0.75) |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | R | — | — |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs… | electron microscopy | R | — | 5 (best 0.72) |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | R | — | — |
| 6PFO | Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with… | x-ray diffraction | A, B | GLC, NAG, SO4 | 10 (best 0.79) |
| 6PFO | Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with… | x-ray diffraction | A, B | NH2, GLC, NAG, SO4 | — |
| 6PGQ | Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with… | x-ray diffraction | A | NH2, GLC, NAG | — |
| 7TYF | Human Amylin1 Receptor in complex with Gs and rat amylin peptide | electron microscopy | R | NAG, PLM, Y01, P42, PTY | — |
| 7TYF | Human AMYLIN1 receptor in complex with gs and rat amylin peptide | electron microscopy | R | NH2, NAG, PLM, Y01, P42, PTY | — |
| 7TYH | Human Amylin2 Receptor in complex with Gs and human calcitonin peptide | electron microscopy | R | — | 5 (best 0.77) |
| 7TYH | Human AMYLIN2 receptor in complex with gs and human calcitonin peptide | electron microscopy | R | NH2 | — |
| 7TYI | Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state | electron microscopy | R | PLM, NAG | 5 (best 0.80) |
| 7TYI | Calcitonin receptor in complex with gs and rat amylin peptide, ct-like state | electron microscopy | R | NH2, PLM, NAG | — |
| 7TYL | Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif | electron microscopy | R | — | 7 (best 0.75) |
| 7TYL | Calcitonin receptor in complex with gs and rat amylin peptide, bypass motif | electron microscopy | R | NH2 | — |
| 7TYN | Calcitonin receptor in complex with gs and salmon calcitonin peptide | electron microscopy | R | NH2, NAG, P42, PLM, Y01 | — |
| 7TYO | Calcitonin receptor in complex with Gs and human calcitonin peptide | electron microscopy | R | NAG, Y01 | 5 (best 0.74) |
| 7TYO | Calcitonin receptor in complex with gs and human calcitonin peptide | electron microscopy | R | NH2, NAG, Y01 | — |
| 7TYW | Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide | electron microscopy | R | PLM, NAG, Y01 | — |
| 7TYW | Human AMYLIN1 receptor in complex with gs and salmon calcitonin peptide | electron microscopy | R | NH2, PLM, NAG, Y01 | — |
| 7TYX | Human Amylin2 Receptor in complex with Gs and rat amylin peptide | electron microscopy | R | PLM, NAG, Y01 | 6 (best 0.75) |
| 7TYX | Human AMYLIN2 receptor in complex with gs and rat amylin peptide | electron microscopy | R | NH2, PLM, NAG, Y01 | — |
| 7TYY | Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide | electron microscopy | R | NAG, PLM, Y01 | 9 (best 0.78) |
| 7TYY | Human AMYLIN2 receptor in complex with gs and salmon calcitonin peptide | electron microscopy | R | NH2, NAG, PLM, Y01 | — |
| 7TZF | Human AMYLIN3 receptor in complex with gs and rat amylin peptide | electron microscopy | R | NH2, P42, NAG, PLM, Y01 | — |
| 8F0J | Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45 | electron microscopy | R | D6M, NAG, PTY, PLM, Y01, P42 | 4 (best 0.77) |
| 8F0K | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 | electron microscopy | R | NAG, P42, PLM, Y01, PTY | 6 (best 0.72) |
| 8F2A | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5… | electron microscopy | R | NAG | 6 (best 0.74) |
| 8F2B | Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45 | electron microscopy | R | D6M, NAG, PLM, P42, Y01 | 7 (best 0.73) |
| 9AUC | Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide | electron microscopy | R | PLM, NAG, Y01 | 8 (best 0.71) |
| P30988 | AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 22 records
- PLM · Palmitic acid · in 16 records
- Y01 · Cholesterol hemisuccinate · in 16 records
- NH2 · Amino group · in 12 records
- P42 · (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate · in 7 records
- PTY · Phosphatidylethanolamine · in 4 records
- GLC · alpha-D-glucopyranose · in 3 records
- D6M · N-hexadecanoyl-L-glutamic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- URE · Urea · in 1 record
Experiment against prediction
- 5II0 chain A against the predicted model P30988: TM-score 0.97, RMSD 0.70 Å
- 5II0 chain A against the predicted model P30988: TM-score 0.97, RMSD 0.70 Å
- 5UZ7 chain R against the predicted model P30988: TM-score 0.96, RMSD 1.42 Å
- 5UZ7 chain R against the predicted model P30988: TM-score 0.96, RMSD 1.42 Å
- 6NIY chain R against the predicted model P30988: TM-score 0.96, RMSD 1.43 Å
- 6NIY chain R against the predicted model P30988: TM-score 0.96, RMSD 1.43 Å
- 5II0 chain C against the predicted model P30988: TM-score 0.94, RMSD 1.16 Å
- 5II0 chain C against the predicted model P30988: TM-score 0.94, RMSD 1.16 Å
- 5II0 chain B against the predicted model P30988: TM-score 0.93, RMSD 1.28 Å
- 5II0 chain B against the predicted model P30988: TM-score 0.93, RMSD 1.28 Å
Elsewhere
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