MolNFT v2 · #196035 · protein
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
7TYF: “Human Amylin1 Receptor in complex with Gs and rat amylin peptide”. Electron microscopy at 2.2, 5 ligands (PLM, Y01, P42). MolNFT v2 #196035 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TYF
- Type
- protein
- Length
- 1,266 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT
- UniProt
- P63092, P62873, O60894, P59768, P12969, P30988
- Ligands
- PLM, Y01, P42, PTY, NAG
Structure
electron microscopy · resolution 2.2 · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 228 | — | P63092 |
| B | — | protein | 339 | — | P62873 |
| E | — | protein | 112 | — | O60894 |
| G | — | protein | 55 | — | P59768 |
| N | — | protein | 128 | — | — |
| P | — | protein | 37 | — | P12969 |
| R | — | protein | 367 | — | P30988 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 9 copies · chains R, E
- Y01 · Cholesterol hemisuccinate · ligand · 2 copies · chains R
- P42 · (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate · ligand · chains P, R
- PTY · Phosphatidylethanolamine · ligand · chains R
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7TYF · Human AMYLIN1 receptor in complex with gs and rat amylin peptide · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.94
- P30988 · AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) · a predicted model of the same protein · chain R against A, TM-score 0.85
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.84
- P12969 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P12969) · a predicted model of the same protein · chain P against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt O60894
- Every structure of UniProt P59768
- Every structure of UniProt P12969
- Every structure of UniProt P30988
- Elsewhere: RCSB PDB 7TYF · PDBe 7TYF · UniProt P63092 · UniProt P62873 · UniProt O60894 · UniProt P59768 · UniProt P12969 · UniProt P30988
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